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Tissue and plasma levels of galectins in patients with high grade serous ovarian carcinoma as new predictive biomarkers
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Tissue and plasma levels of galectins in patients with high grade serous ovarian carcinoma as new predictive biomarkers
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Journal Article
Tissue and plasma levels of galectins in patients with high grade serous ovarian carcinoma as new predictive biomarkers
2017
Overview
Galectins are moving closer to center stage in detecting glycosylation aberration in cancer cells. Here, we have investigated the expression of galectins in ovarian cancer (OC) and examined their potential as biomarkers in tissues and blood plasma samples of high grade serous ovarian carcinoma (HGSC) patients. In tissues, we found that increased protein expression of stromal gal-1 and epithelial gal-8/9 was associated with a poor response to treatment of HGSC patients. Gal-8/9 were both independent predictors of chemoresistance and overall survival (OS), respectively. This galectin signature increased the predictive value of the cancer antigen 125 (CA125) on 5-year disease-free survival (DFS), post-chemotherapy treatment and 5-year OS. In CA125
LOW
patients, epithelial gal-9 was associated with a lower 5-year OS while stromal gal-1 and epithelial gal-8 were both associated with a lower 5-year DFS. Such negative predictive value of gal-8 and gal-9 was also found using plasma samples. In both cases, high plasma levels of gal-8 and gal-9 was associated with a lower OS and DFS. Overall, these data suggest that galectins may be promising biomarkers to identify subgroups of HGSC patients with poorer prognosis. Our study also contributes to better define the heterogeneity of the disease.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/106
/ 13/51
/ 631/67
/ 82/80
/ Aged
/ Biomarkers, Tumor - metabolism
/ Cystadenocarcinoma, Serous - blood
/ Cystadenocarcinoma, Serous - metabolism
/ Cystadenocarcinoma, Serous - pathology
/ Female
/ Humanities and Social Sciences
/ Humans
/ Neoplasms, Glandular and Epithelial - blood
/ Neoplasms, Glandular and Epithelial - metabolism
/ Ovarian Neoplasms - metabolism
/ Ovarian Neoplasms - pathology
/ Plasma
/ Science
