Asset Details
Do you wish to reserve the book?
A Prospective Investigation of Body Size, Body Fat Composition and Colorectal Cancer Risk in the UK Biobank
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A Prospective Investigation of Body Size, Body Fat Composition and Colorectal Cancer Risk in the UK Biobank
Do you wish to request the book?
A Prospective Investigation of Body Size, Body Fat Composition and Colorectal Cancer Risk in the UK Biobank
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A Prospective Investigation of Body Size, Body Fat Composition and Colorectal Cancer Risk in the UK Biobank
2017
Overview
Obesity has been consistently associated with a greater colorectal cancer risk, but this relationship is weaker among women. In the UK Biobank, we investigated the associations between body size (body mass index [BMI], height, waist circumference, and waist-to-hip ratio) and body fat composition (total body fat percentage and trunk fat percentage) measurements with colorectal cancer risk among 472,526 men and women followed for 5.6 years on average. Multivariable hazard ratios (HRs) and 95% confidence intervals (95%CI) for developing colorectal cancer (2,636 incident cases) were estimated using Cox proportional hazards models. Among men, when the highest and lowest fifths were compared, BMI (HR = 1.35, 95%CI: 1.13–1.61; P
trend
< 0.0001), waist circumference (HR = 1.66, 95%CI: 1.39–1.99; P
trend
< 0.0001), waist-to-hip ratio (HR = 1.58, 95%CI: 1.31–1.91; P
trend
< 0.0001), total body fat percentage (HR = 1.27, 95%CI: 1.06–1.53; P
trend
= 0.002), and trunk fat percentage (HR = 1.31, 95%CI: 1.09–1.58; P
trend
= 0.002) were associated with greater colorectal cancer risk. For women, only waist-to-hip ratio (HR for highest versus lowest fifth = 1.33, 95%CI: 1.08–1.65; P
trend
= 0.005) was positively associated with colorectal cancer risk. Greater body size (overall and abdominal adiposity) was positively associated with colorectal cancer development in men. For women, abdominal adiposity, rather than overall body size, was associated with a greater colorectal cancer risk.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 692/499
/ Body Composition - physiology
/ Body fat
/ Body Fat Distribution - methods
/ Colorectal Neoplasms - etiology
/ Colorectal Neoplasms - metabolism
/ Colorectal Neoplasms - physiopathology
/ Female
/ Hip
/ Humanities and Social Sciences
/ Humans
/ Male
/ Obesity, Abdominal - complications
/ Science
/ Waist Circumference - physiology
/ Women
