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microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation
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microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation
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Journal Article
microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation
2019
Overview
Treatment for chronic diabetic foot ulcers is limited by the inability to simultaneously address the excessive inflammation and impaired re-epithelization and remodeling. Impaired re-epithelization leads to significantly delayed wound closure and excessive inflammation causes tissue destruction, both enhancing wound pathogen colonization. Among many differentially expressed microRNAs, miR-155 is significantly upregulated and fibroblast growth factor 7 (FGF7) mRNA (target of miR-155) and protein are suppressed in diabetic skin, when compared to controls, leading us to hypothesize that topical miR-155 inhibition would improve diabetic wound healing by restoring FGF7 expression.
In vitro
inhibition of miR-155 increased human keratinocyte scratch closure and topical inhibition of miR-155
in vivo
in wounds increased murine FGF7 protein expression and significantly enhanced diabetic wound healing. Moreover, we show that miR-155 inhibition leads to a reduction in wound inflammation, in accordance with known pro-inflammatory actions of miR-155. Our results demonstrate, for the first time, that topical miR-155 inhibition increases diabetic wound fibroblast growth factor 7 expression in diabetic wounds, which, in turn, increases re-epithelization and, consequently, accelerates wound closure. Topical miR-155 inhibition targets both excessive inflammation and impaired re-epithelization and remodeling, being a potentially new and effective treatment for chronic diabetic foot ulcers.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 14/63
/ 38/77
/ 45/61
/ 59
/ 64/60
/ Animals
/ Diabetes
/ Diabetes Mellitus, Experimental - metabolism
/ Feet
/ Fibroblast Growth Factor 7 - genetics
/ Fibroblast Growth Factor 7 - metabolism
/ Fibroblast growth factor receptor 7
/ Humanities and Social Sciences
/ Humans
/ Male
/ Mice
/ miRNA
/ mRNA
/ Re-Epithelialization - physiology
/ Science
/ Skin
/ Ulcers
