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Farnesoid X receptor and bile acids regulate vitamin A storage
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Journal Article
Farnesoid X receptor and bile acids regulate vitamin A storage
2019
Overview
The nuclear receptor Farnesoid X Receptor (FXR) is activated by bile acids and controls multiple metabolic processes, including bile acid, lipid, carbohydrate, amino acid and energy metabolism. Vitamin A is needed for proper metabolic and immune control and requires bile acids for efficient intestinal absorption and storage in the liver. Here, we analyzed whether FXR regulates vitamin A metabolism. Compared to control animals, FXR-null mice showed strongly reduced (>90%) hepatic levels of retinol and retinyl palmitate and a significant reduction in lecithin retinol acyltransferase (LRAT), the enzyme responsible for hepatic vitamin A storage. Hepatic reintroduction of FXR in FXR-null mice induced vitamin A storage in the liver. Hepatic vitamin A levels were normal in intestine-specific FXR-null mice. Obeticholic acid (OCA, 3 weeks) treatment rapidly reduced (>60%) hepatic retinyl palmitate levels in mice, concurrent with strongly increased retinol levels (>5-fold). Similar, but milder effects were observed in cholic acid (12 weeks)-treated mice. OCA did not change hepatic LRAT protein levels, but strongly reduced all enzymes involved in hepatic retinyl ester hydrolysis, involving mostly post-transcriptional mechanisms. In conclusion, vitamin A metabolism in the mouse liver heavily depends on the FXR and FXR-targeted therapies may be prone to cause vitamin A-related pathologies.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 38/1
/ 38/109
/ 42/41
/ 64/110
/ 64/60
/ 82/16
/ 82/80
/ Acyltransferases - metabolism
/ Animals
/ Bile
/ Bile Acids and Salts - metabolism
/ Bile Acids and Salts - pharmacology
/ Chenodeoxycholic Acid - analogs & derivatives
/ Chenodeoxycholic Acid - metabolism
/ Chenodeoxycholic Acid - pharmacology
/ Humanities and Social Sciences
/ Lecithin
/ Liver
/ Mice
/ Receptors, Cytoplasmic and Nuclear - metabolism
/ Rodents
/ Science
