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Immune sensing of food allergens promotes avoidance behaviour
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Journal Article
Immune sensing of food allergens promotes avoidance behaviour
2023
Overview
In addition to its canonical function of protection from pathogens, the immune system can also alter behaviour
1
,
2
. The scope and mechanisms of behavioural modifications by the immune system are not yet well understood. Here, using mouse models of food allergy, we show that allergic sensitization drives antigen-specific avoidance behaviour. Allergen ingestion activates brain areas involved in the response to aversive stimuli, including the nucleus of tractus solitarius, parabrachial nucleus and central amygdala. Allergen avoidance requires immunoglobulin E (IgE) antibodies and mast cells but precedes the development of gut allergic inflammation. The ability of allergen-specific IgE and mast cells to promote avoidance requires cysteinyl leukotrienes and growth and differentiation factor 15. Finally, a comparison of C57BL/6 and BALB/c mouse strains revealed a strong effect of the genetic background on the avoidance behaviour. These findings thus point to antigen-specific behavioural modifications that probably evolved to promote niche selection to avoid unfavourable environments.
A study using mouse models of food allergy shows that allergic sensitization drives antigen-specific avoidance behaviour mediated by immunoglobulin E antibodies and mast cells.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Amygdala
/ Animals
/ Antigens
/ Avoidance Learning - physiology
/ Brain
/ Central Amygdaloid Nucleus - physiology
/ Food
/ Food Hypersensitivity - genetics
/ Food Hypersensitivity - immunology
/ Humanities and Social Sciences
/ Immunoglobulin E - immunology
/ Mice
/ Parabrachial Nucleus - physiology
/ Science
