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Functional ultrasound imaging of intrinsic connectivity in the living rat brain with high spatiotemporal resolution
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Functional ultrasound imaging of intrinsic connectivity in the living rat brain with high spatiotemporal resolution
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Journal Article
Functional ultrasound imaging of intrinsic connectivity in the living rat brain with high spatiotemporal resolution
2014
Overview
Long-range coherences in spontaneous brain activity reflect functional connectivity. Here we propose a novel, highly resolved connectivity mapping approach, using ultrafast functional ultrasound (fUS), which enables imaging of cerebral microvascular haemodynamics deep in the anaesthetized rodent brain, through a large thinned-skull cranial window, with pixel dimensions of 100 μm × 100 μm in-plane. The millisecond-range temporal resolution allows unambiguous cancellation of low-frequency cardio-respiratory noise. Both seed-based and singular value decomposition analysis of spatial coherences in the low-frequency (<0.1 Hz) spontaneous fUS signal fluctuations reproducibly report, at different coronal planes, overlapping high-contrast, intrinsic functional connectivity patterns. These patterns are similar to major functional networks described in humans by resting-state fMRI, such as the lateral task-dependent network putatively anticorrelated with the midline default-mode network. These results introduce fUS as a powerful novel neuroimaging method, which could be extended to portable systems for three-dimensional functional connectivity imaging in awake and freely moving rodents.
Functional connectivity of brain networks is poorly understood, in part, due to limited imaging approaches. Here, the authors use ultrasound imaging to study functional connectivity in the adult rat brain
in vivo
, allowing for the identification of highly contrasted intrinsic connectivity patterns.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Pub. Group
Subject
