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Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer

by Phung, De , Hussain, Maha , Sternberg, Cora N , Shore, Neal , Ferreira, Ubirajara , Rathenborg, Per , Fizazi, Karim , Krivoshik, Andrew , Saad, Fred , Ivashchenko, Petro , Demirhan, Eren , Modelska, Katharina

in Adenocarcinoma - blood / Adenocarcinoma - drug therapy / Adenocarcinoma - mortality / Adenocarcinoma - secondary / Aged / Aged, 80 and over / Androgens / Antigens / Antineoplastic Agents - adverse effects / Antineoplastic Agents - therapeutic use / Cancer therapies / Castration / Chemotherapy / Death / Disease-Free Survival / Double-Blind Method / Hospitals / Humans / Kallikreins - blood / Kaplan-Meier Estimate / Male / Medical imaging / Mens health / Metastases / Metastasis / Middle Aged / Neoplasm Metastasis - prevention & control / Patients / Phenylthiohydantoin - adverse effects / Phenylthiohydantoin - analogs & derivatives / Phenylthiohydantoin - therapeutic use / Prostate cancer / Prostate-specific antigen / Prostate-Specific Antigen - blood / Prostatic Neoplasms, Castration-Resistant - blood / Prostatic Neoplasms, Castration-Resistant - drug therapy / Prostatic Neoplasms, Castration-Resistant - mortality / Prostatic Neoplasms, Castration-Resistant - pathology / Quality of Life / Survival / Time Factors

2018

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Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer

2018

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Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer

2018

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Journal Article

Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer

Phung, De,

Hussain, Maha,

Sternberg, Cora N,

Shore, Neal,

Ferreira, Ubirajara,

Rathenborg, Per,

Fizazi, Karim,

Krivoshik, Andrew,

Saad, Fred,

Ivashchenko, Petro,

Demirhan, Eren,

Modelska, Katharina

2018

Overview

In a trial, the median metastasis-free survival among men with nonmetastatic, castration-resistant prostate cancer and a short PSA doubling time was 36.6 months with enzalutamide and 14.7 months with placebo. Falls and heart problems were more common with enzalutamide.

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Publisher

Massachusetts Medical Society

Subject

Adenocarcinoma - blood

/ Adenocarcinoma - drug therapy

/ Adenocarcinoma - mortality

/ Adenocarcinoma - secondary

/ Aged

/ Aged, 80 and over

/ Androgens