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Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe

by Auderset, Floriane , Combescure, Christophe , Fernandes, José F , Yerly, Sabine , Dayer, Julie-Anne , Dahlke, Christine , Jambrecina, Alen , Strecker, Thomas , Moorthy, Vasee , Hooper, Jay , Kabwende, Anita L , Addo, Marylyn M , Grobusch, Martin P , Matthey, Alain , Becker, Stephan , Njuguna, Patricia , Kieny, Marie-Paule , Siegrist, Claire-Anne , Lohse, Ansgar W , Fast, Patricia , Desmeules, Jules , Kaiser, Laurent , Kaya, Gürkan , Schmiedel, Stefan , Finckh, Axel , Agnandji, Selidji T , Bejon, Philip , Staines, Henry M , Silvera, Peter , Lell, Bertrand , Nolting, Anne , Bache, Emmanuel B , Brosnahan, Jessica S , Eickmann, Markus , Zaki, Sherif , Stubbe, Hans C , Stahl, Felix R , Borregaard, Saskia , Kimani, Domtila , Burrow, Rebekah , Schmidt-Chanasit, Jonas , Lemaître, Barbara , Adegnika, Akim A , Ogwang, Caroline , Biedenkopf, Nadine , Kraehling, Verena , Kasonta, Rahel , Kremsner, Peter G , Massinga-Loembe, Marguerite , Tsofa, Benjamin , Fehling, Sarah K , Goncalves, Ana Rita , Huttner, Angela , Zinser, Madeleine E , Mordmüller, Benjamin , Ramharter, Michael , Krishna, Sanjeev , Altfeld, Marcus

in Adult / Age / Antibodies, Viral - blood / Arthritis / Arthritis - etiology / Clinical trials / Dermatitis - etiology / Double-Blind Method / Ebola Vaccines - administration & dosage / Ebola Vaccines - adverse effects / Ebola Vaccines - immunology / Ebola virus / Ebolavirus - immunology / Ebolavirus - isolation & purification / Exanthema - etiology / Female / Fever / Hemorrhagic Fever, Ebola - immunology / Hemorrhagic Fever, Ebola - prevention & control / Humans / Immunization / Immunogenicity / Joint diseases / Male / Membrane Glycoproteins - immunology / Middle Aged / Pain / Public health / Recombinant Proteins / Replication / Safety / Saliva / Skin / Stomatitis / Urine / Vaccines / Vesiculovirus / Viral Envelope Proteins - immunology / Viremia / Virus Shedding

2016

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Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe

2016

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2016

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Journal Article

Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe

Auderset, Floriane,

Combescure, Christophe,

Fernandes, José F,

Yerly, Sabine,

Dayer, Julie-Anne,

Dahlke, Christine,

Jambrecina, Alen,

Strecker, Thomas,

Moorthy, Vasee,

Hooper, Jay,

Kabwende, Anita L,

Addo, Marylyn M,

Grobusch, Martin P,

Matthey, Alain,

Becker, Stephan,

Njuguna, Patricia,

Kieny, Marie-Paule,

Siegrist, Claire-Anne,

Lohse, Ansgar W,

Fast, Patricia,

Desmeules, Jules,

Kaiser, Laurent,

Kaya, Gürkan,

Schmiedel, Stefan,

Finckh, Axel,

Agnandji, Selidji T,

Bejon, Philip,

Staines, Henry M,

Silvera, Peter,

Lell, Bertrand,

Nolting, Anne,

Bache, Emmanuel B,

Brosnahan, Jessica S,

Eickmann, Markus,

Zaki, Sherif,

Stubbe, Hans C,

Stahl, Felix R,

Borregaard, Saskia,

Kimani, Domtila,

Burrow, Rebekah,

Schmidt-Chanasit, Jonas,

Lemaître, Barbara,

Adegnika, Akim A,

Ogwang, Caroline,

Biedenkopf, Nadine,

Kraehling, Verena,

Kasonta, Rahel,

Kremsner, Peter G,

Massinga-Loembe, Marguerite,

Tsofa, Benjamin,

Fehling, Sarah K,

Goncalves, Ana Rita,

Huttner, Angela,

Zinser, Madeleine E,

Mordmüller, Benjamin,

Ramharter, Michael,

Krishna, Sanjeev,

Altfeld, Marcus

2016

Overview

In this set of four phase 1 studies, a recombinant vesicular stomatitis virus (rVSV)–based Ebola vaccine induced Ebola virus–specific immune responses and was associated with side effects that included fever and transient arthritis, rash, and VSV viremia. In August 2014, after the outbreak of Ebola virus disease was declared a public health emergency of international concern by the World Health Organization (WHO), the Canadian government donated 800 vials of the replication-competent recombinant vesicular stomatitis virus (rVSV)–vectored Zaire ebolavirus (rVSV-ZEBOV) candidate vaccine to the WHO. The VSV Ebola Consortium (VEBCON) was created under the auspices of the WHO to initiate phase 1 studies to facilitate rapid progression to phase 2 and 3 trials in affected countries. 1 Live replicating viral vaccines elicit humoral and cellular immune responses against viral pathogens. 2 , 3 A single injection of 10 million plaque-forming units . . .

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Age

/ Antibodies, Viral - blood

/ Arthritis

/ Arthritis - etiology

/ Clinical trials

/ Dermatitis - etiology