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Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

by Brandwein, Joseph M , Sierra, Jorge , Döhner, Konstanze , Krauter, Jürgen , de Witte, Theo , Mandrekar, Sumithra J , Döhner, Hartmut , Appelbaum, Frederick R , Sanford, Ben L , Larson, Richard A , Ehninger, Gerhard , Amadori, Sergio , Prior, Thomas W , Wei, Andrew , Lo-Coco, Francesco , Medeiros, Bruno C , Marcucci, Guido , Ganser, Arnold , Niederwieser, Dietger , Bloomfield, Clara D , Serve, Hubert , Laumann, Kristina , Tallman, Martin S , Geyer, Susan , Thiede, Christian , Schlenk, Richard F , Klisovic, Rebecca B , Sanz, Miguel A , Stone, Richard M

in Acute myeloid leukemia / Adolescent / Adult / Antineoplastic Combined Chemotherapy Protocols - adverse effects / Antineoplastic Combined Chemotherapy Protocols - therapeutic use / Cancer therapies / Chemotherapy / Clinical trials / Cytarabine / Cytarabine - administration & dosage / Daunorubicin / Daunorubicin - administration & dosage / Death / Drug dosages / Enzyme inhibitors / Female / fms-Like Tyrosine Kinase 3 - genetics / Humans / Induction therapy / Inhibitor drugs / Kaplan-Meier Estimate / Kinases / Leukemia / Leukemia, Myeloid, Acute - drug therapy / Leukemia, Myeloid, Acute - genetics / Leukemia, Myeloid, Acute - mortality / Male / Medical prognosis / Medical research / Middle Aged / Mutation / Myeloid leukemia / Oncology / Patients / Point mutation / Protein Kinase Inhibitors - administration & dosage / Protein Kinase Inhibitors - adverse effects / Protein-tyrosine kinase / Remission / Staurosporine - administration & dosage / Staurosporine - adverse effects / Staurosporine - analogs & derivatives / Survival / Transplantation / Young Adult

2017

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Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

2017

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Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

2017

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Journal Article

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

Brandwein, Joseph M,

Sierra, Jorge,

Döhner, Konstanze,

Krauter, Jürgen,

de Witte, Theo,

Mandrekar, Sumithra J,

Döhner, Hartmut,

Appelbaum, Frederick R,

Sanford, Ben L,

Larson, Richard A,

Ehninger, Gerhard,

Amadori, Sergio,

Prior, Thomas W,

Wei, Andrew,

Lo-Coco, Francesco,

Medeiros, Bruno C,

Marcucci, Guido,

Ganser, Arnold,

Niederwieser, Dietger,

Bloomfield, Clara D,

Serve, Hubert,

Laumann, Kristina,

Tallman, Martin S,

Geyer, Susan,

Thiede, Christian,

Schlenk, Richard F,

Klisovic, Rebecca B,

Sanz, Miguel A,

Stone, Richard M

2017

Overview

Midostaurin, an oral multitargeted kinase inhibitor, is active in patients with a FLT3 mutation. Among patients with acute myeloid leukemia and this mutation, the addition of midostaurin to standard chemotherapy appeared to improve long-term outcomes.

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Publisher

Massachusetts Medical Society

Subject

Acute myeloid leukemia

/ Adolescent

/ Adult

/ Antineoplastic Combined Chemotherapy Protocols - adverse effects

/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use

/ Cancer therapies

/ Chemotherapy