Asset Details
Do you wish to reserve the book?
Environmental Exposure to Bisphenol A Enhances Invasiveness in Papillary Thyroid Cancer
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Environmental Exposure to Bisphenol A Enhances Invasiveness in Papillary Thyroid Cancer
Do you wish to request the book?
Environmental Exposure to Bisphenol A Enhances Invasiveness in Papillary Thyroid Cancer
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Environmental Exposure to Bisphenol A Enhances Invasiveness in Papillary Thyroid Cancer
2025
Overview
Bisphenol A (BPA) is a prevalent environmental contaminant found in plastics and known for its endocrine-disrupting properties, posing risks to both human health and the environment. Despite its widespread presence, the impact of BPA on papillary thyroid cancer (PTC) progression, especially under realistic environmental conditions, is not well understood. This study examined the effects of BPA on PTC using a 3D thyroid papillary tumor spheroid model, which better mimicked the complex interactions within human tissues compared to traditional 2D models. Our findings demonstrated that BPA, at environmentally relevant concentrations, could induce significant changes in PTC cells, including a decrease in E-cadherin expression, an increase in vimentin expression, and reduced thyroglobulin (TG) secretion. These changes suggest that BPA exposure may promote epithelial–mesenchymal transition (EMT), enhance invasiveness, and reduce cell differentiation, potentially complicating treatment, including by increasing resistance to radioiodine therapy. This research highlights BPA’s hazardous nature as an environmental contaminant and emphasizes the need for advanced in vitro models, like 3D tumor spheroids, to better assess the risks posed by such chemicals. It provides valuable insights into the environmental implications of BPA and its role in thyroid cancer progression, enhancing our understanding of endocrine-disrupting chemicals.
Publisher
MDPI AG,MDPI
Subject
/ Benzhydryl Compounds - toxicity
/ Cancer
/ Endocrine Disruptors - toxicity
/ Environmental Exposure - adverse effects
/ Epithelial-Mesenchymal Transition - drug effects
/ Humans
/ Mutation
/ Phenols
/ Spheroids, Cellular - drug effects
/ Thyroid Cancer, Papillary - metabolism
/ Thyroid Cancer, Papillary - pathology
/ Thyroid Neoplasms - metabolism
/ Thyroid Neoplasms - pathology
/ Toxicity
/ Tumors
