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Therapeutic Performance of Needle Injection Versus Needle‐Free Jet Injector System for Polynucleotide Filler in Skin Rejuvenation
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Therapeutic Performance of Needle Injection Versus Needle‐Free Jet Injector System for Polynucleotide Filler in Skin Rejuvenation
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Therapeutic Performance of Needle Injection Versus Needle‐Free Jet Injector System for Polynucleotide Filler in Skin Rejuvenation
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Journal Article
Therapeutic Performance of Needle Injection Versus Needle‐Free Jet Injector System for Polynucleotide Filler in Skin Rejuvenation
2025
Overview
Background Polynucleotide (PN) filler often causes pain and can lead to delivery inaccuracies when applied via intradermal injection using a traditional needle. Aims To evaluate the efficacy of treatment and the pain during the procedure using conventional needle injection versus a needle‐free jet system for intradermal PN filler application. Methods In this split‐face clinical trial, 10 Korean subjects were enrolled. Each subject received an intradermal injection of PN filler on one side of the face and a needle‐free jet injection using CureJet on the other side. Assessments included global and 3D skin imaging at each visit. Pain intensity was evaluated using visual analogue scale (VAS) scores during the injection. Additionally, patient satisfaction and adverse events were documented. Results Findings revealed that Global Aesthetic Improvement Scale scores and patient satisfaction were significantly higher with the CureJet compared to the needle injection method. VAS scores were notably lower on the CureJet side. Improvements in both pore and wrinkle indices were observed from baseline, with a more pronounced improvement rate on the CureJet side compared to the needle injection side. Conclusions Needle‐free injection of PN for aging skin was found to be effective in enhancing pore and wrinkle improvement, while reducing associated discomfort.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc
Subject
/ Aging
/ Collagen
/ Cosmetic Techniques - adverse effects
/ Cosmetic Techniques - instrumentation
/ Dermal Fillers - administration & dosage
/ Dermal Fillers - adverse effects
/ Erythema
/ Face
/ Female
/ Humans
/ Injections, Intradermal - adverse effects
/ Injections, Intradermal - instrumentation
/ Injections, Intradermal - methods
/ Injections, Jet - adverse effects
/ Injections, Jet - instrumentation
/ Male
/ Needles
/ Original
/ Pain
/ Pain, Procedural - diagnosis
/ pore
/ Skin
/ wrinkle
