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MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells
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MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells
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Journal Article
MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells
2016
Overview
Background:
MicroRNA-214
(
miR-214
) has been shown to act as a tumour suppressor in human cervical and colorectal cancer cells. The aim of this study was to experimentally validate high mobility group AT-hook 1 as a novel target for
miR-214-
mediated suppression of growth and motility.
Methods:
HMGA1
and
miR-214
expression levels were estimated in cervical and colorectal clinical specimens using qPCR.
HMGA1
3′ untranslated region luciferase assays were performed to validate
HMGA1
as a target of
miR-214
. Effect of altering the expression of
miR-214
or
HMGA1
on proliferation, migration and invasion of human cervical and colorectal cancer cells was investigated.
Results:
miR-214
expression was poor while that of
HMGA1
was high in cervical and colorectal cancer tissues.
miR-214
-re-expression or
HMGA1
downregulation inhibited proliferation, migration and invasion of cancer cells while
miR-214
inhibition had opposite effects.
miR-214
was demonstrated to bind to the wild-type 3′ untranslated region of
HMGA1
but not with its mutant.
Conclusions:
Low expression of
miR-214
concurrent with elevated levels of
HMGA1
may contribute to cervical and colorectal cancer progression.
miR-214
-mediated regulation of
HMGA1
is a novel mechanism for its tumour-suppressive actions in human cervical and colorectal cancer cells and opens up avenues for novel therapeutic strategies for these two cancers.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
3' Untranslated Regions - genetics
/ Biomedical and Life Sciences
/ Colorectal Neoplasms - genetics
/ Colorectal Neoplasms - pathology
/ Female
/ Gene Expression Regulation, Neoplastic
/ HMGA1a Protein - antagonists & inhibitors
/ HMGA1a Protein - biosynthesis
/ Humans
/ LDCs
/ Male
/ Neoplasm Proteins - antagonists & inhibitors
/ Neoplasm Proteins - biosynthesis
/ Neoplasm Proteins - genetics
/ Neoplasm Proteins - physiology
/ Oncology
/ Proteins
/ RNA, Small Interfering - genetics
