Journal Article

Escherichia coli Shiga Toxins and Gut Microbiota Interactions

Lee, Kyung-Soo, Jeong, Yu-Jin, Lee, Moo-Seung

2021

Overview

Escherichia coli (EHEC) and Shigella dysenteriae serotype 1 are enterohemorrhagic bacteria that induce hemorrhagic colitis. This, in turn, may result in potentially lethal complications, such as hemolytic uremic syndrome (HUS), which is characterized by thrombocytopenia, acute renal failure, and neurological abnormalities. Both species of bacteria produce Shiga toxins (Stxs), a phage-encoded exotoxin inhibiting protein synthesis in host cells that are primarily responsible for bacterial virulence. Although most studies have focused on the pathogenic roles of Stxs as harmful substances capable of inducing cell death and as proinflammatory factors that sensitize the host target organs to damage, less is known about the interface between the commensalism of bacterial communities and the pathogenicity of the toxins. The gut contains more species of bacteria than any other organ, providing pathogenic bacteria that colonize the gut with a greater number of opportunities to encounter other bacterial species. Notably, the presence in the intestines of pathogenic EHEC producing Stxs associated with severe illness may have compounding effects on the diversity of the indigenous bacteria and bacterial communities in the gut. The present review focuses on studies describing the roles of Stxs in the complex interactions between pathogenic Shiga toxin-producing E. coli, the resident microbiome, and host tissues. The determination of these interactions may provide insights into the unresolved issues regarding these pathogens.

• Publisher: MDPI AG,MDPI
• Subject: Abnormalities / Animals / Autophagy / Bacteria / bacterial toxins / Cell death / Colitis / commensal microbes / Commensalism / Compounding effects / Cytotoxicity / E coli / Endoplasmic reticulum / Epidemics / Escherichia coli / Escherichia coli Infections - microbiology / Exotoxins / Gastrointestinal Microbiome - drug effects / Gut microbiota / Hemolytic uremic syndrome / Hemorrhage / Humans / Inflammation / Inflammatory bowel disease / Intestinal microflora / Intestine / Kidneys / Microbiomes / Microbiota / Neurophysiology / Organs / Pathogenesis / Pathogenicity / Pathogens / Phages / Probiotics / Protein biosynthesis / Protein synthesis / Proteins / Public health / Renal failure / Review / Shiga toxin / Shiga toxin types 1 and 2 / Shiga toxins / Shiga Toxins - toxicity / Shiga-Toxigenic Escherichia coli / Shiga-toxin-producing Escherichia coli (STEC) / Species / Thrombocytopenia / Toxins / Virulence