Journal Article

Radiotherapy and Short-Term Androgen Deprivation for Localized Prostate Cancer

Sandler, Howard M, Jones, Christopher U, Souhami, Luis, Rotman, Marvin, Shipley, William U, Husain, Siraj M, Hunt, Daniel, Amin, Mahul B, Leibenhaut, Mark H, Chetner, Michael P, Bruner, Deborah W, McGowan, David G

2011

Overview

A course of androgen-deprivation therapy before and during radiotherapy prolonged 10-year survival by about 7% among men with intermediate-risk prostate cancer. The risk of erectile dysfunction from the addition of hormone therapy was also about 7% higher. In the 1980s, advances in both surgery and radiotherapy for clinically localized prostate cancer led to their acceptance as successful treatments, with considerable reductions in harmful side effects as compared with earlier treatments. 1 In the 1990s, reversible androgen suppression with the use of luteinizing hormone–releasing hormone analogues and oral antiandrogen agents was shown to induce apoptotic regression in androgen-responsive cancers, 2 potentially improving the prospects of local control and the duration of survival free of metastatic disease. Among patients with locally advanced disease, phase 3 clinical trials 3 , 4 showed that when added to radiotherapy, long-term treatment with these agents (≥2 years) . . .

• Publisher: Massachusetts Medical Society
• Subject: Adenocarcinoma / Aged / Aged, 80 and over / Androgen Antagonists - adverse effects / Androgen Antagonists - therapeutic use / Androgens / Antineoplastic Combined Chemotherapy Protocols - adverse effects / Antineoplastic Combined Chemotherapy Protocols - therapeutic use / Biological and medical sciences / Biopsy / Blood tests / Cancer therapies / Combined Modality Therapy / Erectile Dysfunction - etiology / Flutamide - administration & dosage / Flutamide - adverse effects / Follow-Up Studies / General aspects / Gonadotropin-Releasing Hormone - agonists / Gonadotropin-Releasing Hormone - therapeutic use / Goserelin - administration & dosage / Goserelin - adverse effects / Gynecology. Andrology. Obstetrics / Humans / Leuprolide - administration & dosage / Leuprolide - adverse effects / Lymphatic system / Male / Male genital diseases / Medical sciences / Metastases / Metastasis / Middle Aged / Mortality / Multivariate Analysis / Nephrology. Urinary tract diseases / Oncology / Phosphatase / Prostate - pathology / Prostate cancer / Prostate-specific antigen / Prostatic Neoplasms - drug therapy / Prostatic Neoplasms - mortality / Prostatic Neoplasms - pathology / Prostatic Neoplasms - radiotherapy / Radiation therapy / Radiotherapy - adverse effects / Radiotherapy Dosage / Risk / Short term / Surgery / Survival / Survival Rate / Tumors / Tumors of the urinary system / Urinary tract. Prostate gland