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Identification and analysis of differentially expressed lncRNAs and their ceRNA networks in DMD/mdx primary myoblasts
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Identification and analysis of differentially expressed lncRNAs and their ceRNA networks in DMD/mdx primary myoblasts
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Journal Article
Identification and analysis of differentially expressed lncRNAs and their ceRNA networks in DMD/mdx primary myoblasts
2024
Overview
This study explored the significance of long non-coding RNAs (lncRNAs), particularly their role in maintaining dystrophin protein stability and regulating myocyte proliferation and differentiation. The investigation focused on DMD/mdx mouse skeletal muscle primary myoblasts, aiming to identify lncRNAs potential as biomarkers and therapeutic targets for Duchenne muscular dystrophy (DMD). Utilizing CLC Genomics Workbench software, 554 differentially expressed lncRNAs were identified in DMD/mdx mice compared to wild-type (WT) control. Among them, 373 were upregulated, and 181 were downregulated. The study highlighted specific lncRNAs (e.g., 5930430L01Rik, Gm10143, LncRNA1490, LncRNA580) and their potential regulatory roles in DMD key genes like
IGF1
,
FN1
,
TNNI1
, and
MYOD1
. By predicting miRNA and their connections with lncRNA and mRNA (ceRNA network) using tools such as miRNet, miRSYSTEM and miRCARTA, the study revealed potential indirect regulation of
Dystrophin
,
IGF1R
and
UTRN
genes by identified lncRNAs (e.g. 2310001H17Rik-203, C130073E24Rik-202, LncRNA2767, 5930430L01Rik and LncRNA580). These findings suggest that the identified lncRNAs may play crucial roles in the development and progression of DMD through their regulatory influence on key gene expression, providing valuable insights for potential therapeutic interventions.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Animals
/ Atrophy
/ Duchenne's muscular dystrophy
/ Genomes
/ Genomics
/ Humanities and Social Sciences
/ Insulin-like growth factor I
/ Kinases
/ Mice
/ miRNA
/ Muscular Dystrophy, Duchenne - genetics
/ Muscular Dystrophy, Duchenne - metabolism
/ Muscular Dystrophy, Duchenne - pathology
/ Myocytes
/ Proteins
/ RNA, Long Noncoding - genetics
/ Science
/ Zoology
