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Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes
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Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes
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Journal Article
Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes
2024
Overview
The main vectors of Zika virus (ZIKV) and dengue virus (DENV) are
Aedes aegypti
and
Ae. albopictus
, with
Ae. aegypti
being more competent. However, the underlying mechanisms remain unclear. Here, we find
Ae. albopictus
shows comparable vector competence to ZIKV/DENV with
Ae. aegypti
by blood-feeding after antibiotic treatment or intrathoracic injection. This suggests that midgut microbiota can influence vector competence.
Enterobacter hormaechei
_B17 (Eh_B17) is isolated from field-collected
Ae. albopictus
and conferred resistance to ZIKV/DENV infection in
Ae. aegypti
after gut-transplantation. Sphingosine, a metabolite secreted by Eh_B17, effectively suppresses ZIKV infection in both
Ae. aegypti
and cell cultures by blocking viral entry during the fusion step, with an IC
50
of approximately 10 μM. A field survey reveals that Eh_B17 preferentially colonizes
Ae. albopictus
compared to
Ae. aegypti
. And field
Ae. albopictus
positive for Eh_B17 are more resistant to ZIKV infection. These findings underscore the potential of gut symbiotic bacteria, such as Eh_B17, to modulate the arbovirus vector competence of
Aedes
mosquitoes. As a natural antiviral agent, Eh_B17 holds promise as a potential candidate for blocking ZIKV/DENV transmission.
Here the authors show that arbovirus vector competence of
Aedes mosquitoes
is modulated by the midgut microbiota and identify the metabolite sphingosine from the gut symbiotic bacterium
Enterobacter hormaechei_B17
(Eh_B17) as a factor mediating resistance to ZIKV and DENV infection.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 140/58
/ 45/43
/ 49/22
/ 49/23
/ 49/39
/ 49/90
/ 96/1
/ Aedes
/ Animals
/ Bacteria
/ Dengue - prevention & control
/ Female
/ Gastrointestinal Microbiome - drug effects
/ Humanities and Social Sciences
/ Humans
/ Midgut
/ Mosquito Vectors - drug effects
/ Mosquito Vectors - microbiology
/ Science
/ Sphingosine - analogs & derivatives
/ Vectors
/ Virus Internalization - drug effects
