Asset Details
Do you wish to reserve the book?
Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo
Do you wish to request the book?
Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo
2024
Overview
Hematopoietic stem cells (HSCs) produce all essential cellular components of the blood. Stromal cell lines supporting HSCs follow a vascular smooth muscle cell (vSMC) differentiation pathway, suggesting that some hematopoiesis-supporting cells originate from vSMC precursors. These pericyte-like precursors were recently identified in the aorta-gonad-mesonephros (AGM) region; however, their role in the hematopoietic development in vivo remains unknown. Here, we identify a subpopulation of NG2
+
Runx1
+
perivascular cells that display a sclerotome-derived vSMC transcriptomic profile. We show that deleting Runx1 in NG2
+
cells impairs the hematopoietic development in vivo and causes transcriptional changes in pericytes/vSMCs, endothelial cells and hematopoietic cells in the murine AGM. Importantly, this deletion leads also to a significant reduction of HSC reconstitution potential in the bone marrow in vivo. This defect is developmental, as NG2
+
Runx1
+
cells were not detected in the adult bone marrow, demonstrating the existence of a specialised pericyte population in the HSC-generating niche, unique to the embryo.
Hematopoietic stem cells are supported by niche cells that help balance stem cell self-renewal and differentiation. Here they show that Runx1 deletion in the embryonic perivascular HSC niche impairs hematopoietic development in vivo and causes transcriptional changes in pericytes/vSMCs, endothelial cells and hematopoietic cells in the murine AGM.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/106
/ 13/31
/ 13/51
/ 14
/ 14/63
/ 38
/ 38/91
/ 631/80
/ Animals
/ Aorta
/ Core Binding Factor Alpha 2 Subunit - genetics
/ Core Binding Factor Alpha 2 Subunit - metabolism
/ Deletion
/ Endothelial Cells - metabolism
/ Hematopoietic Stem Cells - metabolism
/ Humanities and Social Sciences
/ Mice
/ Muscle, Smooth, Vascular - metabolism
/ Muscles
/ Science
