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CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus
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CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus
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CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus
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Journal Article
CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus
2023
Overview
Culex
mosquitoes pose a significant public health threat as vectors for a variety of diseases including West Nile virus and lymphatic filariasis, and transmit pathogens threatening livestock, companion animals, and endangered birds. Rampant insecticide resistance makes controlling these mosquitoes challenging and necessitates the development of new control strategies. Gene drive technologies have made significant progress in other mosquito species, although similar advances have been lagging in
Culex
. Here we test a CRISPR-based homing gene drive for
Culex quinquefasciatus
, and show that the inheritance of two split-gene-drive transgenes, targeting different loci, are biased in the presence of a Cas9-expressing transgene although with modest efficiencies. Our findings extend the list of disease vectors where engineered homing gene drives have been demonstrated to include
Culex
alongside
Anopheles
and
Aedes
, and pave the way for future development of these technologies to control
Culex
mosquitoes.
Culex mosquitoes are carriers of major diseases like West Nile virus and are a public health concern. Here the authors present a CRISPR-Cas9 gene drive as a control technology in the Culex quinquefasciatus mosquito species.
