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Genetic variants regulating the immune response improve the prediction of COVID-19 severity provided by clinical variables
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Journal Article
Genetic variants regulating the immune response improve the prediction of COVID-19 severity provided by clinical variables
2024
Overview
The characteristics of the host are crucial in the final outcome of COVID-19. Herein, the influence of genetic and clinical variants in COVID-19 severity was investigated in a total of 1350 patients. Twenty-one single nucleotide polymorphisms of genes involved in SARS-CoV-2 sensing as Toll-like-Receptor 7, antiviral immunity as the type I interferon signalling pathway (
TYK2, STAT1, STAT4, OAS1, SOCS
) and the vasoactive intestinal peptide and its receptors (
VIP/VIPR1,2
) were studied. To analyse the association between polymorphisms and severity, a model adjusted by age, sex and different comorbidities was generated by ordinal logistic regression. The genotypes rs8108236-AA (OR 0.12 [95% CI 0.02–0.53];
p
= 0.007) and rs280519-AG (OR 0.74 [95% CI 0.56–0.99];
p
= 0.03) in
TYK2
, and rs688136-CC (OR 0.7 [95% CI 0.5–0.99];
p
= 0.046) in
VIP,
were associated with lower severity; in contrast, rs3853839-GG in
TLR7
(OR 1.44 [95% CI 1.07–1.94];
p
= 0.016), rs280500-AG (OR 1.33 [95% CI 0.97–1.82];
p
= 0.078) in
TYK2
and rs1131454-AA in
OAS1
(OR 1.29 [95% CI 0.95–1.75];
p
= 0.110) were associated with higher severity. Therefore, these variants could influence the risk of severe COVID-19.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
2',5'-Oligoadenylate Synthetase - genetics
/ 631/208
/ 631/250
/ 692/53
/ Adult
/ Aged
/ COVID-19
/ Female
/ Genetic Predisposition to Disease
/ Genotype
/ Humanities and Social Sciences
/ Humans
/ Male
/ Polymorphism, Single Nucleotide
/ Science
/ Severe acute respiratory syndrome coronavirus 2
/ Single-nucleotide polymorphism
