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Ultralong transients enhance sensitivity and resolution in Orbitrap-based single-ion mass spectrometry

by Ebberink, Eduard H. T. M. , Deslignière, Evolène , Kozhinov, Anton N. , Nagornov, Konstantin O. , Heck, Albert J. R. , Makarov, Alexander A. , Barendregt, Arjan , Yin, Victor C. , Fort, Kyle L. , Wörner, Tobias P. , Rolland, Amber D. , Tsybin, Yury O.

in 631/45/475 / 631/57/2265 / Accuracy / Bioinformatics / Biological Microscopy / Biological Techniques / Biomedical and Life Sciences / Biomedical Engineering/Biotechnology / Data acquisition / Electrons / Fourier transforms / Ions / Life Sciences / Macromolecules / Mass spectrometers / Mass spectrometry / Mass spectroscopy / Proteomics / Scientific imaging / Sensitivity analysis / Sensitivity enhancement / Signal processing / Signal to noise ratio

2024

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Ultralong transients enhance sensitivity and resolution in Orbitrap-based single-ion mass spectrometry

2024

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Ultralong transients enhance sensitivity and resolution in Orbitrap-based single-ion mass spectrometry

2024

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Journal Article

Ultralong transients enhance sensitivity and resolution in Orbitrap-based single-ion mass spectrometry

Ebberink, Eduard H. T. M.,

Deslignière, Evolène,

Kozhinov, Anton N.,

Nagornov, Konstantin O.,

Heck, Albert J. R.,

Makarov, Alexander A.,

Barendregt, Arjan,

Yin, Victor C.,

Fort, Kyle L.,

Wörner, Tobias P.,

Rolland, Amber D.,

Tsybin, Yury O.

2024

Overview

Orbitrap-based charge detection mass spectrometry utilizes single-molecule sensitivity to enable mass analysis of even highly heterogeneous, high-mass macromolecular assemblies. For contemporary Orbitrap instruments, the accessible ion detection (recording) times are maximally ~1–2 s. Here by modifying a data acquisition method on an Orbitrap ultrahigh mass range mass spectrometer, we trapped and monitored individual (single) ions for up to 25 s, resulting in a corresponding and huge improvement in signal-to-noise ratio (×5 compared with 1 s), mass resolution (×25) and accuracy in charge and mass determination of Orbitrap-based charge detection mass spectrometry. Implementation of ultralong transients on an Orbitrap mass spectrometer improves mass resolution, sensitivity and accuracy of charge determination in the analysis of large macromolecular ions.

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ Biological Microscopy

/ Biological Techniques

/ Biomedical and Life Sciences