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Biological function and potential application of PANoptosis-related genes in colorectal carcinogenesis
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Biological function and potential application of PANoptosis-related genes in colorectal carcinogenesis
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Biological function and potential application of PANoptosis-related genes in colorectal carcinogenesis
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Journal Article
Biological function and potential application of PANoptosis-related genes in colorectal carcinogenesis
2024
Overview
PANoptosis induces programmed cell death (PCD) through extensive crosstalk and is associated with development of cancer. However, the functional mechanisms, clinical significance, and potential applications of PANoptosis-related genes (PRGs) in colorectal cancer (CRC) have not been fully elucidated. Functional enrichment of key PRGs was analyzed based on databases, and relationships between key PRGs and the immune microenvironment, immune cell infiltration, chemotherapy drug sensitivity, tumor progression genes, single-cell cellular subgroups, signal transduction pathways, transcription factor regulation, and miRNA regulatory networks were systematically explored. This study identified 5 key PRGs associated with CRC:
BCL10
,
CDKN2A
,
DAPK1
,
PYGM
and
TIMP1
. Then, RT-PCR was used to verify expression of these genes in CRC cells and tissues. Clinical significance and prognostic value of key genes were further verified by multiple datasets. Analyses of the immune microenvironment, immune cell infiltration, chemotherapy drug sensitivity, tumor progression genes, single-cell cellular subgroups, and signal transduction pathways suggest a close relationship between these key genes and development of CRC. In addition, a novel prognostic nomogram model for CRC was successfully constructed by combining important clinical indicators and the key genes. In conclusion, our findings offer new insights for understanding the pathogenesis of CRC, predicting CRC prognosis, and identifying multiple therapeutic targets for future CRC therapy.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/208
/ 631/67
/ 692/4020
/ 692/4028
/ Biomarkers, Tumor - genetics
/ Chemotherapy drug sensitivity
/ Colorectal Neoplasms - genetics
/ Colorectal Neoplasms - pathology
/ Cyclin-Dependent Kinase Inhibitor p16 - genetics
/ Cyclin-Dependent Kinase Inhibitor p16 - metabolism
/ Death-associated protein kinase
/ Death-Associated Protein Kinases - genetics
/ Death-Associated Protein Kinases - metabolism
/ Gene Expression Regulation, Neoplastic
/ Humanities and Social Sciences
/ Humans
/ miRNA
/ Nomogram
/ Science
/ Tissue inhibitor of metalloproteinase 1
/ Tissue Inhibitor of Metalloproteinase-1 - genetics
/ Tissue Inhibitor of Metalloproteinase-1 - metabolism
/ Tumor Microenvironment - genetics
/ Tumors
