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Increased and synergistic RNAi delivery using MOF polydopamine nanoparticles for biopesticide applications
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Increased and synergistic RNAi delivery using MOF polydopamine nanoparticles for biopesticide applications
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Journal Article
Increased and synergistic RNAi delivery using MOF polydopamine nanoparticles for biopesticide applications
2025
Overview
RNA interference is an eco-friendly alternative to chemical pesticides, yet its efficacy in lepidopterans like
Spodoptera frugiperda
(
S. frugiperda
) is limited by poor uptake. Here, we report on ZIF-8 polydopamine nanoparticles that protect dsRNA against enzymatic degradation and active the endocytic/phagosome pathways for increased uptake. Furthermore, the uptake of nano-enabled dsRNA induces the overgrowth of
Serratia marcescens
, this reduces the
S. frugiperda
reactive oxygen species (ROS) immune response, increasing the effects of plant’s natural defenses, further inhibiting
Enteroccous mundtii
growth. This work shows the synergistic potential of nanoparticles for influencing the gut bacteria to prevent resistance mechanisms and for RNAi delivery for pest management.
RNA interference therapy has huge potential in pesticide applications, however delivery and stability remain an issue. Here, the authors report on a metal-organic framework, polydopamine nanoparticle for increasing delivery and stability of RNA to plants. Demonstrating application in targeting the fall armyworm.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 147/143
/ 38
/ 38/23
/ 38/77
/ 38/89
/ 45/41
/ 82/1
/ 82/58
/ Animals
/ Biological Control Agents - pharmacology
/ Corn
/ Humanities and Social Sciences
/ Insects
/ Reactive Oxygen Species - metabolism
/ RNA, Double-Stranded - genetics
/ Science
/ Serratia marcescens - drug effects
