Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Evaluation of Electrochemotherapy with Bleomycin in the Treatment of Colorectal Hepatic Metastases in a Rat Model

by Wagenpfeil, Gudrun , Laschke, Matthias W. , Gäbelein, Gereon , Holländer, Sebastian , Nika, Spyridon , Rudzitis-Auth, Jeannette , Mallis Kyriakides, Orestis , Menger, Michael D. , Glanemann, Matthias , Spiliotis, Antonios E. , Eisele, Robert

in Ablation / Apoptosis / Bleomycin / Body temperature / Cancer / Care and treatment / Cell membranes / Chemotherapy / Colorectal cancer / Cytotoxicity / Development and progression / Dosage and administration / Electric fields / Electric properties / Electroconvulsive therapy / Electrodes / Electroporation / Evaluation / Experiments / Hemoglobin / Immunohistochemistry / Integrated software / Laboratory animals / Laparotomy / Liver / Liver cancer / Membrane permeability / Metastases / Metastasis / Necrosis / Oxygenation / Permeability / Skin cancer / Testing / Tumor cells / Tumors / Ultrasonic imaging / Vascularization

2023

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Evaluation of Electrochemotherapy with Bleomycin in the Treatment of Colorectal Hepatic Metastases in a Rat Model

2023

Confirm

Do you wish to request the book?

Evaluation of Electrochemotherapy with Bleomycin in the Treatment of Colorectal Hepatic Metastases in a Rat Model

2023

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Evaluation of Electrochemotherapy with Bleomycin in the Treatment of Colorectal Hepatic Metastases in a Rat Model

Wagenpfeil, Gudrun,

Laschke, Matthias W.,

Gäbelein, Gereon,

Holländer, Sebastian,

Nika, Spyridon,

Rudzitis-Auth, Jeannette,

Mallis Kyriakides, Orestis,

Menger, Michael D.,

Glanemann, Matthias,

Spiliotis, Antonios E.,

Eisele, Robert

2023

Overview

Background: The available ablative procedures for the treatment of hepatic cancer have contraindications due to the heat-sink effect and the risk of thermal injuries. Electrochemotherapy (ECT) as a nonthermal approach may be utilized for the treatment of tumors adjacent to high-risk regions. We evaluated the effectiveness of ECT in a rat model. Methods: WAG/Rij rats were randomized to four groups and underwent ECT, reversible electroporation (rEP), or intravenous injection of bleomycin (BLM) eight days after subcapsular hepatic tumor implantation. The fourth group served as Sham. Tumor volume and oxygenation were measured before and five days after the treatment using ultrasound and photoacoustic imaging; thereafter, liver and tumor tissue were additionally analysed by histology and immunohistochemistry. Results: The ECT group showed a stronger reduction in tumor oxygenation compared to the rEP and BLM groups; moreover, ECT-treated tumors exhibited the lowest levels of hemoglobin concentration compared to the other groups. Histological analyses further revealed a significantly increased tumor necrosis of >85% and a reduced tumor vascularization in the ECT group compared to the rEP, BLM, and Sham groups. Conclusion: ECT is an effective approach for the treatment of hepatic tumors with necrosis rates >85% five days following treatment.

Share this book

Add to My Shelf

Publisher

MDPI AG,MDPI

Subject

/ Cancer