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Gut Microbiome Profiles Are Associated With Type 2 Diabetes in Urban Africans
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Journal Article
Gut Microbiome Profiles Are Associated With Type 2 Diabetes in Urban Africans
2020
Overview
Gut dysbiosis has been associated with several disease outcomes including diabetes in human populations. Currently, there are no studies of the gut microbiome composition in relation to type 2 diabetes (T2D) in Africans. Here, we describe the profile of the gut microbiome in non-diabetic adults (controls) and investigate the association between gut microbiota and T2D in urban West Africans. Gut microbiota composition was determined in 291 Nigerians (98 cases, 193 controls) using fecal 16S V4 rRNA gene sequencing done on the Illumina MiSeq platform. Data analysis of operational taxonomic units (OTU) was conducted to describe microbiome composition and identify differences between T2D and controls. The most abundant phyla were
, and
.
, and
were significantly lower in cases than controls (
< 0.001). Feature selection analysis identified a panel of 18 OTUs enriched in cases that included
. A panel of 17 OTUs that was enriched in the controls included
, and
. OTUs with strain-level annotation showing the largest fold-change included
(log
FC = -3.1;
= 4.2 × 10
),
(log
FC = -2.5;
= 0.005),
(log
FC = -1.76;
= 0.01), all lower in cases. These findings are notable because supplementation with
and
has been shown to improve hyperglycemia and reduce insulin resistance in murine models. This first investigation of gut microbiome and diabetes in urban Africans shows that T2D is associated with compositional changes in gut microbiota highlighting the possibility of developing strategies to improve glucose control by modifying bacterial composition in the gut.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Actinobacteria - classification
/ Actinobacteria - isolation & purification
/ African Continental Ancestry Group
/ Bacteroidetes - classification
/ Bacteroidetes - isolation & purification
/ Cellular and Infection Microbiology
/ Diabetes
/ Diabetes mellitus (non-insulin dependent)
/ Diabetes Mellitus, Type 2 - drug therapy
/ Diabetes Mellitus, Type 2 - microbiology
/ Disease
/ Female
/ Firmicutes - isolation & purification
/ Glucose
/ Humans
/ Hypoglycemic Agents - therapeutic use
/ Male
/ Nigeria
/ rRNA 16S
/ Taxonomy
