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Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway

by Stark, Alexander , Sachidanandam, Ravi , McLaughlin, K. John , Reuter, Michael , Eckardt, Sigrid , Pillai, Ramesh S. , Leu, N. Adrian , Xiol, Jordi , Zheng, Ke , Wang, Peijing Jeremy , Hogan, Brigid L. M.

in Animals / Antibodies / Argonaute Proteins / Base Sequence / biogenesis / Biological Sciences / Biosynthesis / Cells / Derepression / DNA Methylation / DNA Primers - genetics / Drosophila / Fertility / Genetics / Germ cells / Male / males / Meiosis / Mice / Mice, Knockout / mutants / Mutation / Pachytene stage / Proteins / Proteins - metabolism / Retroelements - genetics / Retrotransposons / Ribonucleoproteins, Small Nuclear - genetics / Ribonucleoproteins, Small Nuclear - metabolism / RNA / RNA helicase / RNA helicases / RNA Helicases - deficiency / RNA Helicases - genetics / RNA Helicases - metabolism / RNA, Small Interfering - genetics / RNA, Small Interfering - metabolism / Rodents / small interfering RNA / Spermatocytes / Spermatocytes - metabolism / Spermatogenesis / Spermatogonia / Spermatogonia - metabolism / Testes / Testis - metabolism / Transposons

2010

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Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway

2010

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Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway

2010

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Journal Article

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway

Stark, Alexander,

Sachidanandam, Ravi,

McLaughlin, K. John,

Reuter, Michael,

Eckardt, Sigrid,

Pillai, Ramesh S.,

Leu, N. Adrian,

Xiol, Jordi,

Zheng, Ke,

Wang, Peijing Jeremy,

Hogan, Brigid L. M.

2010

Overview

Piwi-interacting RNAs (piRNAs) are essential for silencing of transposable elements in the germline, but their biogenesis is poorly understood. Here we demonstrate that MOV10L1, a germ cell—specific putative RNA helicase, is associated with Piwi proteins. Genetic disruption of the MOV10L1 RNA helicase domain in mice renders both MILI and MIWI2 devoid of piRNAs. Absence of a functional piRNA pathway in Mov10l1 mutant testes causes loss of DNA methylation and subsequent derepression of retrotransposons in germ cells. The Mov10l1 mutant males are sterile owing to complete meiotic arrest. This mouse mutant expresses Piwi proteins but lacks piRNAs, suggesting that MOV10L1 is required for piRNA biogenesis and/or loading to Piwi proteins.

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Publisher

National Academy of Sciences,National Acad Sciences

Subject

/ Biological Sciences

/ Biosynthesis