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IFN-γ, IL-2, IP-10, and MIG as Biomarkers of Exposure to Leishmania spp., and of Cure in Human Visceral Leishmaniasis
by
Ghosh, Prakash
, Alvar, Jorge
, Ibarra-Meneses, Ana V.
, Chowdhury, Rajashree
, Moreno, Javier
, Hossain, Faria
, Mondal, Dinesh
, Carrillo, Eugenia
in
Adult
/ Antigens
/ Asymptomatic
/ Bangladesh
/ biomarker
/ Biomarkers
/ Biomarkers - blood
/ Blood & organ donations
/ Blood banks
/ chemokine
/ Chemokine CXCL10 - blood
/ Chemokine CXCL9 - blood
/ Chemokines
/ Chemokines - blood
/ cytokine
/ Cytokines
/ Cytokines - blood
/ DNA, Protozoan - analysis
/ Female
/ Hospitals
/ Humans
/ Immune response
/ Immune response (cell-mediated)
/ Immunity, Cellular
/ Infections
/ Interferon-gamma - blood
/ Interleukin 2
/ Interleukin-2 - blood
/ IP-10 protein
/ Leishmania
/ Leishmania - genetics
/ Leishmania - immunology
/ Leishmania - pathogenicity
/ Leishmania donovani - immunology
/ Leishmania donovani - pathogenicity
/ Leishmania infantum - immunology
/ Leishmania infantum - pathogenicity
/ leishmaniasis
/ Leishmaniasis, Visceral - blood
/ Leishmaniasis, Visceral - diagnosis
/ Leishmaniasis, Visceral - therapy
/ Male
/ Microbiology
/ Middle Aged
/ Parasites
/ Parasitic diseases
/ Plasma
/ Proteins
/ Protozoa
/ Software
/ Spain
/ Tropical diseases
/ Visceral leishmaniasis
/ whole blood assay
/ γ-Interferon
2017
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IFN-γ, IL-2, IP-10, and MIG as Biomarkers of Exposure to Leishmania spp., and of Cure in Human Visceral Leishmaniasis
by
Ghosh, Prakash
, Alvar, Jorge
, Ibarra-Meneses, Ana V.
, Chowdhury, Rajashree
, Moreno, Javier
, Hossain, Faria
, Mondal, Dinesh
, Carrillo, Eugenia
in
Adult
/ Antigens
/ Asymptomatic
/ Bangladesh
/ biomarker
/ Biomarkers
/ Biomarkers - blood
/ Blood & organ donations
/ Blood banks
/ chemokine
/ Chemokine CXCL10 - blood
/ Chemokine CXCL9 - blood
/ Chemokines
/ Chemokines - blood
/ cytokine
/ Cytokines
/ Cytokines - blood
/ DNA, Protozoan - analysis
/ Female
/ Hospitals
/ Humans
/ Immune response
/ Immune response (cell-mediated)
/ Immunity, Cellular
/ Infections
/ Interferon-gamma - blood
/ Interleukin 2
/ Interleukin-2 - blood
/ IP-10 protein
/ Leishmania
/ Leishmania - genetics
/ Leishmania - immunology
/ Leishmania - pathogenicity
/ Leishmania donovani - immunology
/ Leishmania donovani - pathogenicity
/ Leishmania infantum - immunology
/ Leishmania infantum - pathogenicity
/ leishmaniasis
/ Leishmaniasis, Visceral - blood
/ Leishmaniasis, Visceral - diagnosis
/ Leishmaniasis, Visceral - therapy
/ Male
/ Microbiology
/ Middle Aged
/ Parasites
/ Parasitic diseases
/ Plasma
/ Proteins
/ Protozoa
/ Software
/ Spain
/ Tropical diseases
/ Visceral leishmaniasis
/ whole blood assay
/ γ-Interferon
2017
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IFN-γ, IL-2, IP-10, and MIG as Biomarkers of Exposure to Leishmania spp., and of Cure in Human Visceral Leishmaniasis
by
Ghosh, Prakash
, Alvar, Jorge
, Ibarra-Meneses, Ana V.
, Chowdhury, Rajashree
, Moreno, Javier
, Hossain, Faria
, Mondal, Dinesh
, Carrillo, Eugenia
in
Adult
/ Antigens
/ Asymptomatic
/ Bangladesh
/ biomarker
/ Biomarkers
/ Biomarkers - blood
/ Blood & organ donations
/ Blood banks
/ chemokine
/ Chemokine CXCL10 - blood
/ Chemokine CXCL9 - blood
/ Chemokines
/ Chemokines - blood
/ cytokine
/ Cytokines
/ Cytokines - blood
/ DNA, Protozoan - analysis
/ Female
/ Hospitals
/ Humans
/ Immune response
/ Immune response (cell-mediated)
/ Immunity, Cellular
/ Infections
/ Interferon-gamma - blood
/ Interleukin 2
/ Interleukin-2 - blood
/ IP-10 protein
/ Leishmania
/ Leishmania - genetics
/ Leishmania - immunology
/ Leishmania - pathogenicity
/ Leishmania donovani - immunology
/ Leishmania donovani - pathogenicity
/ Leishmania infantum - immunology
/ Leishmania infantum - pathogenicity
/ leishmaniasis
/ Leishmaniasis, Visceral - blood
/ Leishmaniasis, Visceral - diagnosis
/ Leishmaniasis, Visceral - therapy
/ Male
/ Microbiology
/ Middle Aged
/ Parasites
/ Parasitic diseases
/ Plasma
/ Proteins
/ Protozoa
/ Software
/ Spain
/ Tropical diseases
/ Visceral leishmaniasis
/ whole blood assay
/ γ-Interferon
2017
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IFN-γ, IL-2, IP-10, and MIG as Biomarkers of Exposure to Leishmania spp., and of Cure in Human Visceral Leishmaniasis
Journal Article
IFN-γ, IL-2, IP-10, and MIG as Biomarkers of Exposure to Leishmania spp., and of Cure in Human Visceral Leishmaniasis
2017
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Overview
New biomarkers are needed for monitoring the effectiveness of treatment for visceral leishmaniasis (VL). They might also improve the detection of the asymptomatic population in
endemic areas. This paper examines the IL-2, IFN-γ, IFN-γ-induced protein 10 (IP-10), and monokine-induced-by-IFN-γ (MIG) levels in whole blood-stimulated
with soluble
antigen (SLA)-taken from asymptomatic individuals and patients treated for VL living in a post-outbreak (
) area in Spain, and in an endemic (
) area of Bangladesh. IP-10 was found to be an accurate global marker of asymptomatic subjects with positive cellular/humoral tests, while MIG was found to be a better marker of contact with
than IL-2 but no for those with
. Determining IP-10, MIG, and IFN-γ levels proved useful in monitoring the cellular immune response following treatment for active disease caused by
.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Antigens
/ cytokine
/ Female
/ Humans
/ Immune response (cell-mediated)
/ Leishmania donovani - immunology
/ Leishmania donovani - pathogenicity
/ Leishmania infantum - immunology
/ Leishmania infantum - pathogenicity
/ Leishmaniasis, Visceral - blood
/ Leishmaniasis, Visceral - diagnosis
/ Leishmaniasis, Visceral - therapy
/ Male
/ Plasma
/ Proteins
/ Protozoa
/ Software
/ Spain
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