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AP-2α gene deregulation is associated with renal cell carcinoma patient survival
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Journal Article
AP-2α gene deregulation is associated with renal cell carcinoma patient survival
2024
Overview
Background
Renal cell carcinoma (RCC), one of the most fatal urologic tumors, accounts for approximately 3% of all adult cancers and exhibits a high metastatic index at diagnosis and a high rate of relapse. Radical or partial nephrectomy is a curative option for nonmetastatic RCCs. Targeted therapy has been shown to improve the survival of patients with metastatic RCCs. However, the underlying cellular and molecular events associated with RCC pathogenesis are not well known.
Methods
To investigate the clinical role of the transcription factor activator protein (AP)-2α in RCC, methylated CpG island recovery assays and microarray analysis were employed. COBRA and RT‒qPCR assays were performed to assess
AP-2α
expression in RCC.
Results
A negative correlation was noted between
AP-2α
mRNA expression levels and methylation status. Multivariate analyses showed that
AP-2α
mRNA was a major risk factor not only for overall and disease-free survival in RCC but also for disease-free survival in clear cell RCC.
Conclusions
Our results indicated that
AP-2α
expression was deregulated in RCC and associated with overall patient survival and disease-free survival. Such findings suggest that AP-2α might play an important role in the pathogenesis of RCC.
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
/ Aged
/ AP-2α
/ Biomedical and Life Sciences
/ Carcinoma, Renal Cell - genetics
/ Carcinoma, Renal Cell - mortality
/ Carcinoma, Renal Cell - pathology
/ Female
/ Gene Expression Regulation, Neoplastic
/ Genes
/ Health Promotion and Disease Prevention
/ Humans
/ Kidney Neoplasms - mortality
/ Kidney Neoplasms - pathology
/ Kinases
/ Male
/ Oncology
/ Patients
/ Software
/ TFAP2A
/ Transcription Factor AP-2 - genetics
/ Transcription Factor AP-2 - metabolism
/ Tumors
