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The potential of the South African plant Tulbaghia Violacea Harv for the treatment of triple negative breast cancer
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The potential of the South African plant Tulbaghia Violacea Harv for the treatment of triple negative breast cancer
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Journal Article
The potential of the South African plant Tulbaghia Violacea Harv for the treatment of triple negative breast cancer
2025
Overview
Triple-negative breast cancer (TNBC) is difficult to treat and has a low five-year survival rate. In South Africa, a large percentage of the population still relies on traditional plant-based medicine. To establish the utility of both methanol and water-soluble extracts from the leaves of
Tulbaghia violacea
, cytotoxicity assays were carried out to establish the IC
50
values against a TNBC cell line. Cell cycle and apoptosis assays were carried out using the extracts. To identify the molecular compounds, present in water-soluble leaf extracts, NMR spectroscopy was performed. Compounds of interest were then used in computational docking studies with the anti-apoptotic protein COX-2. The IC
50
values for the water- and methanol-soluble extracts were determined to be 400 and 820 µg/mL, respectively. The water-soluble extract induced apoptosis in the TNBC cell line to a greater extent than in the normal cell line. RNAseq indicated that there was an increase in the transcription of pro-apoptotic genes in the TNBC cell line. The crude extract also caused these cells to stall in the S phase. Of the 61 compounds identified in this extract, five demonstrated a high binding affinity for COX-2. Based on these findings, the compounds within the extract show significant potential for further investigation as candidates for the development of cancer therapeutics, particularly for TNBC.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 631/337
/ 631/45
/ 631/67
/ Antineoplastic Agents, Phytogenic - chemistry
/ Antineoplastic Agents, Phytogenic - pharmacology
/ Cancer
/ COX-2
/ Cyclooxygenase 2 - chemistry
/ Cyclooxygenase 2 - metabolism
/ Female
/ Humanities and Social Sciences
/ Humans
/ Leaves
/ Magnetic resonance spectroscopy
/ Methanol
/ Molecular compound isolation
/ Molecular Docking Simulation
/ Plant Extracts - pharmacology
/ S phase
/ Science
/ Triple Negative Breast Neoplasms - drug therapy
