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Seminal Papers in Urology: Darolutamide and survival in metastatic, hormone-sensitive prostate cancer
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Seminal Papers in Urology: Darolutamide and survival in metastatic, hormone-sensitive prostate cancer
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Journal Article
Seminal Papers in Urology: Darolutamide and survival in metastatic, hormone-sensitive prostate cancer
2024
Overview
The ARASENS trial recruited 1306 men with metastatic hormone sensitive prostate cancer. It investigated the effect of androgen deprivation therapy (ADT) and systemic therapy docetaxel in combination with a third novel drug – daralutamide, compared with placebo on overall survival. Triple therapy with ADT, docetaxel and darolutamide resulted in improved overall survival rates as compared with ADT, docetaxel and placebo (HR 0.68; 95% CI, 0.57–0.80;
p
< 0.001). The side effect profile for both treatments was similar. This randomised, double blinded, placebo controlled study, was assessed to have a low risk of bias using the Cochrane Risk of Bias 2 tool.
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
Androgen Antagonists - therapeutic use
/ Benzamides - therapeutic use
/ Bias
/ Comment
/ Humans
/ Male
/ Medicine
/ Oncology
/ Placebos
/ Prostatic Neoplasms - drug therapy
/ Prostatic Neoplasms - mortality
/ Prostatic Neoplasms - pathology
/ Randomized Controlled Trials as Topic
/ Survival
/ Urology
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