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B Cells Control Mucosal-Associated Invariant T Cell Responses to Salmonella enterica Serovar Typhi Infection Through the CD85j HLA-G Receptor
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B Cells Control Mucosal-Associated Invariant T Cell Responses to Salmonella enterica Serovar Typhi Infection Through the CD85j HLA-G Receptor
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B Cells Control Mucosal-Associated Invariant T Cell Responses to Salmonella enterica Serovar Typhi Infection Through the CD85j HLA-G Receptor
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Journal Article
B Cells Control Mucosal-Associated Invariant T Cell Responses to Salmonella enterica Serovar Typhi Infection Through the CD85j HLA-G Receptor
2021
Overview
Mucosal-associated invariant T (MAIT) cells are an innate-like population of T cells that display a TCR Vα7.2+ CD161+ phenotype and are restricted by the nonclassical MHC-related molecule 1 (MR1). Although B cells control MAIT cell development and function, little is known about the mechanisms underlying their interaction(s). Here, we report, for the first time, that during Salmonella enterica serovar Typhi ( S . Typhi) infection, HLA-G expression on B cells downregulates IFN-γ production by MAIT cells. In contrast, blocking HLA-G expression on S . Typhi-infected B cells increases IFN-γ production by MAIT cells. After interacting with MAIT cells, kinetic studies show that B cells upregulate HLA-G expression and downregulate the inhibitory HLA-G receptor CD85j on MAIT cells resulting in their loss. These results provide a new role for HLA-G as a negative feedback loop by which B cells control MAIT cell responses to antigens.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ B-Lymphocytes - microbiology
/ Cloning
/ Female
/ Histocompatibility antigen HLA
/ HLA-G
/ human
/ Humans
/ Interferon-gamma - metabolism
/ Kinetics
/ Leukocyte Immunoglobulin-like Receptor B1 - genetics
/ Leukocyte Immunoglobulin-like Receptor B1 - metabolism
/ Major histocompatibility complex
/ Male
/ Mucosa
/ Mucosal-Associated Invariant T Cells - immunology
/ Mucosal-Associated Invariant T Cells - metabolism
/ Mucosal-Associated Invariant T Cells - microbiology
/ S. Typhi
/ Salmonella typhi - immunology
/ Salmonella typhi - pathogenicity
/ Typhoid
