Journal Article

Characterization of the Phytochemical Composition and Bioactivities of Anacyclus maroccanus Ball. and Anacyclus radiatus Loisel Aerial Parts: Preliminary Evidence for the Possible Development of Moroccan Plants

Mazzanti, Gabriela, Macone, Alberto, Toniolo, Chiara, Menghini, Luigi, Vitalone, Annabella, Di Sotto, Antonella, Abdellah, Aghraz, Ferrante, Claudio, Angelini, Paola, Larhsini, Mustapha, Giusti, Anna Maria, Sissi, Saida, Di Giacomo, Silvia, Markouk, Mohammed

2022

Overview

In the present study, the phytochemical composition and bioactivities of A. maroccanus (AM) and A. radiatus (AR), two ecotypes collected in the Demnate road and Essaouira regions, respectively, were studied to highlight a pharmacological interest and to enable possible pharmaceutical development. To this end, methanolic and ethyl acetate extracts were prepared for each ecotype by fractionation; next, their phytochemical composition was evaluated by spectrophotometric and chromatographic analysis. Moreover, in line with the available evidence for Anacyclus spp. and their traditional use, a screening of bioactivities, including antioxidant, hypoglycemic, antiglycative, chelating, and antibacterial activities, was performed. The extracts were characterized by high amounts of polyphenols, tannins, and flavonoids, especially in the methanolic extracts; these samples were also enriched in carotenoids despite a lower chlorophyll content. Chlorogenic acid and rutin were the major identified compounds. The extracts also showed interesting hypoglycemic, antiglycative, and antibacterial properties, although with differences in efficacy and potency. Present results provide more scientific basis to the ethnopharmacological uses of Anacyclus spp. and suggest a further interest in AM and AR ecotypes as natural sources of bioactive compounds and/or phytocomplexes for possible pharmaceutical and nutraceutical developments.

• Publisher: MDPI AG,MDPI
• Subject: advanced glycation end products / Analgesics / Anti-Bacterial Agents - pharmacology / antiglycation activity / Antimicrobial agents / Antioxidants / Antioxidants - chemistry / Asteraceae - drug effects / Asteraceae - genetics / Asteraceae - metabolism / Biodiversity / Carbohydrates / Carotenoids / chelating activity / Chromatography / Ethnobotany / Flavonoids / Flavonoids - analysis / Functional foods & nutraceuticals / Herbal medicine / Hypoglycemia / hypoglycemic activity / Infections / Metabolism / Microbial Sensitivity Tests / Morocco / Oils & fats / Oxidative stress / phenolics / Phytochemicals / Phytochemicals - analysis / Plant Components, Aerial - chemistry / Plant Extracts - chemistry / Polyphenols / Polyphenols - chemistry / Tannins / Traditions / α-glucosidase