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A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease

by Schumann, Michael , Kupcinskas, Juozas , Török, Helga P , Zopf, Yurdagül , Popp, Alina , Kull, Karin , Lundin, Knut E.A , Greinwald, Roland , Isola, Jorma , Lohse, Ansgar W , Stallmach, Andreas , Biedermann, Luc , Jahnsen, Jørgen , Fusco, Stefano , Byrnes, Valerie , Friesing-Sosnik, Tina , Mäki, Markku , Hovde, Øistein , Zeitz, Jonas , Mohrbacher, Ralf , Schuppan, Detlef , Koskenpato, Jari , Lähdeaho, Marja-Leena , Taavela, Juha , Langhorst, Jost , Scheinin, Mika

in 3121 Internal medicine / 3123 Gynaecology and paediatrics / Adverse events / Allergy / Atrophy / Biopsy / Celiac disease / Diarrhea / Diet / Disease / Dosage / Drug dosages / Endoscopy / Epithelial cells / Gastroenterology / Gastroenterology General / Glutamine / Gluten / Hyperplasia / Immunology / Immunology General / Laboratories / Lymphocytes / Lymphocytes T / Medizin / Morphology / Mucosa / Nausea / Nutrition / Patients / Peptides / Placebos / Quality of life / Questionnaires / Small intestine / Transglutaminase 2 / Villus / Vomiting

2021

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A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease

2021

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2021

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Journal Article

A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease

Schumann, Michael,

Kupcinskas, Juozas,

Török, Helga P,

Zopf, Yurdagül,

Popp, Alina,

Kull, Karin,

Lundin, Knut E.A,

Greinwald, Roland,

Isola, Jorma,

Lohse, Ansgar W,

Stallmach, Andreas,

Biedermann, Luc,

Jahnsen, Jørgen,

Fusco, Stefano,

Byrnes, Valerie,

Friesing-Sosnik, Tina,

Mäki, Markku,

Hovde, Øistein,

Zeitz, Jonas,

Mohrbacher, Ralf,

Schuppan, Detlef,

Koskenpato, Jari,

Lähdeaho, Marja-Leena,

Taavela, Juha,

Langhorst, Jost,

Scheinin, Mika

2021

Overview

In a phase 2 proof-of-concept trial, patients with celiac disease controlled on a gluten-free diet were assigned to one of three dose levels of ZED1227 (a selective transglutaminase 2 inhibitor) or placebo. Patients were challenged with 3 g of gluten daily for 6 weeks. Comparison of duodenal-biopsy samples between baseline and 6 weeks showed that ZED1227 attenuated gluten-induced mucosal damage.

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Publisher

Massachusetts Medical Society

Subject

3121 Internal medicine

/ 3123 Gynaecology and paediatrics

/ Adverse events

/ Allergy

/ Atrophy

/ Biopsy

/ Celiac disease