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CDS-PD: a novel clinical decision support platform for Parkinson’s disease

by Iyer, Vivikta , Zweber, Cole , Tatsuoka, Curtis , Prantzalos, Katrina , Zurlo, Ian , Boyd, James T. , Clarke, Dakota , Hiller, Amie L. , Sahoo, Satya S. , Gupta, Deepak K. , Golnari, Pedram , Lobb, Brenna M. , Bulusu, Manu

in 631/114 / 631/378 / 692/617 / 692/699 / Access control / Algorithms / Automation / Clinical decision making / Clinical trials / Consent / Data collection / Decision Support Systems, Clinical / Diagnosis / Electronic health records / Family medical history / Humanities and Social Sciences / Humans / Informatics / Movement disorders / multidisciplinary / Neurodegenerative diseases / Parkinson Disease - diagnosis / Parkinson's disease / Patients / Quality control / Science / Science (multidisciplinary) / Software quality / User interface / Validation studies

2026

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2026

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2026

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Journal Article

CDS-PD: a novel clinical decision support platform for Parkinson’s disease

Iyer, Vivikta,

Zweber, Cole,

Tatsuoka, Curtis,

Prantzalos, Katrina,

Zurlo, Ian,

Boyd, James T.,

Clarke, Dakota,

Hiller, Amie L.,

Sahoo, Satya S.,

Gupta, Deepak K.,

Golnari, Pedram,

Lobb, Brenna M.,

Bulusu, Manu

2026

Overview

The Movement Disorders Society clinical diagnostic criteria for Parkinson’s disease (MDS-PD) allow highly sensitive and specific diagnosis of Parkinson’s disease. However, their adoption has been limited due to lack of a clinical decision support (CDS) tool to support clinicians and researchers in systematically and accurately applying the MDS-PD criteria. We have developed and performed preliminary validation of a CDS platform for PD (CDS-PD) as a modular and extensible informatics platform with comprehensive functionalities for recording relevant patient information. We have performed real-time application of diagnostic algorithm of the MDS-PD criteria. The CDS-PD platform shows high concordance with application of the MDS-PD criteria by experienced movement disorders neurologists for established PD (disease duration ≥ 5 years). The CDS-PD platform is a step towards realizing the standardized electronic implementation of the MDS-PD criteria for PD patient care and clinical trials at point-of-care. The CDS-PD platform can be accessed after registration at weblink https://www.cdspd.org .

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

631/114

/ 631/378

/ 692/617

/ 692/699

/ Access control

/ Algorithms

/ Automation