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CFP1 promotes germinal center affinity maturation and restrains memory B cell differentiation through H3K4me3 modulation
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CFP1 promotes germinal center affinity maturation and restrains memory B cell differentiation through H3K4me3 modulation
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Journal Article
CFP1 promotes germinal center affinity maturation and restrains memory B cell differentiation through H3K4me3 modulation
2025
Overview
Affinity maturation and differentiation of B cells in the germinal center (GC) are tightly controlled by epigenetically regulated transcription programs, but the underlying mechanisms are only partially understood. Here we show that
Cfp1
, an integral component of the histone methyltransferase complex Setd1A/B, is critically required for GC responses.
Cfp1
deficiency in activated B cells greatly impairs GC formation with diminished proliferation, somatic hypermutation and affinity maturation. Mechanistically,
Cfp1
deletion reduces H3K4me3 marks at a subset of cell cycle and GC-related genes and impairs their transcription. Importantly,
Cfp1
promotes the expression of transcription factors MEF2B and OCA-B and the
Bcl6
enhancer-promoter looping for its efficient induction. Accordingly,
Cfp1
-deficient GCB cells upregulate IRF4 and preferentially differentiate into plasmablasts. Furthermore,
Cfp1
ablation upregulates a panel of pre-memory genes with elevated H3K4me3 and leads to markedly expanded memory B populations. In summary, our study reveals that
Cfp1
-safeguarded epigenetic regulation ensures proper dynamics of GCB cells for affinity maturation and prevents the pre-mature exit from GC as memory cells.
Cellular differentiation decisions, such as fates of B cells following entry into the germinal centres, are governed by epigenetically and transcriptionally regulated paths for bifurcating cell fates. Here the authors show that CFP1 is a master epigenetic regulator of activated B cells and controls their hypermutation and affinity maturation via the histone methyltransferase complex Setd1A/B.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/15
/ 45/22
/ 49/91
/ Ablation
/ Affinity
/ Animals
/ Antigens
/ Cell Differentiation - genetics
/ Cell Differentiation - immunology
/ Genes
/ Germinal Center - immunology
/ Germinal Center - metabolism
/ Histone-Lysine N-Methyltransferase - genetics
/ Histone-Lysine N-Methyltransferase - metabolism
/ Histones
/ Humanities and Social Sciences
/ Interferon regulatory factor 4
/ Interferon Regulatory Factors - genetics
/ Interferon Regulatory Factors - metabolism
/ Mice
/ Proto-Oncogene Proteins c-bcl-6 - genetics
/ Proto-Oncogene Proteins c-bcl-6 - metabolism
/ Science
/ Spleen
