Asset Details
Do you wish to reserve the book?
Physicochemical optimization of zinc oxide nanoparticles enhances their antimicrobial and anticancer activities via RmpA, fnbA, cna, and LuxS gene expression suppression
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Physicochemical optimization of zinc oxide nanoparticles enhances their antimicrobial and anticancer activities via RmpA, fnbA, cna, and LuxS gene expression suppression
Do you wish to request the book?
Physicochemical optimization of zinc oxide nanoparticles enhances their antimicrobial and anticancer activities via RmpA, fnbA, cna, and LuxS gene expression suppression
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Physicochemical optimization of zinc oxide nanoparticles enhances their antimicrobial and anticancer activities via RmpA, fnbA, cna, and LuxS gene expression suppression
2026
Overview
Zinc oxide nanoparticles (ZnO-NPs) have gained attention for their anticancer and antimicrobial activity. Our study highlights a novel anti-virulence strategy against multidrug-resistant pathogens by showing that ZnO-NPs suppress bacterial virulence and quorum-sensing genes (
rmpA
,
fnbA
,
cna
, and
LuxS
) at sub-MIC levels. In this study, we synthesized ZnO-NPs using the chemical co-precipitation process, we confirmed their characteristics with the techniques TEM, XRD, UV-Vis spectroscopy, and measuring their zeta potential. ZnO-NPs are almost spherical, 30 nanometers in size, with a notable UV absorption at 375 nm and a zeta potential of -9.25 mV. ZnO-NPs showed impressive inhibition zones, especially against
E. coli
, with a zone size of 30.33 mm. The MIC of ZnO-NPs varied, with
Staphylococcus aureus
needing the highest concentration at 500 µg/mL, while
E. coli
and
Pseudomonas aeruginosa
needed 62.5 and 125 µg/mL, respectively. We also looked at how these particles affect cancer cells and found they reduced their growth in a dose-dependent way, with IC50 values of around 79 and 151 µg/mL for MCF-7 and HepG2 cells. Interestingly, when we examined the bacteria at the genetic level, we saw that ZnO-NPs at 62.5 µg/mL resulted in down-expression of key virulence genes like
rmpA
,
fnbA
, and
cna
to about 60% of normal levels, and the quorum-sensing gene
luxS
to 80%. This suggests that even at lower doses, the particles can weaken bacterial ability to cause disease without being fully bactericidal. Overall, our results emphasize how ZnO-NPs can be both antibacterial and anticancer agents, especially by targeting gene expression to boost their effectiveness.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
