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Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle
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Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle
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Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle
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Journal Article
Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle
2006
Overview
Stem cells hold a great potential for the regeneration of damaged tissues in cardiovascular or musculoskeletal diseases. Unfortunately, problems such as limited availability, control of cell fate, and allograft rejection need to be addressed before therapeutic applications may become feasible. Generation of multipotent progenitors from adult differentiated cells could be a very attractive alternative to the limited
in vitro
self-renewal of several types of stem cells. In this direction, a recently synthesized unnatural purine, named reversine, has been proposed to induce reversion of adult cells to a multipotent state, which could be then converted into other cell types under appropriate stimuli. Our study suggests that reversine treatment transforms primary murine and human dermal fibroblasts into myogenic-competent cells both
in vitro
and
in vivo
. Moreover, this is the first study to demonstrate that plasticity changes arise in primary mouse and human cells following reversine exposure.
Publisher
Nature Publishing Group UK,Nature Publishing Group
