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Metabotropic glutamate receptor 5 expression associates with pain and inflammatory pathways in interstitial cystitis
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Metabotropic glutamate receptor 5 expression associates with pain and inflammatory pathways in interstitial cystitis
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Journal Article
Metabotropic glutamate receptor 5 expression associates with pain and inflammatory pathways in interstitial cystitis
2026
Overview
Interstitial cystitis (IC)/bladder pain syndrome (BPS) is a chronic condition with severe pelvic pain and urinary symptoms significantly impairing quality of life. This study investigated the clinical relevance of the metabotropic glutamate receptor (mGluR) family in IC/BPS. Bladder biopsy samples were taken from 61 patients, including 42 Hunner-type IC, 11 non-Hunner type IC, and 8 controls without IC. Gene expression analysis revealed that mGluR2, mGluR3, and mGluR5 were significantly elevated in patients with IC/BPS compared to controls. Among these, mGluR5 showed the strongest association with pain severity, fibrosis, and lymphoplasmacytic infiltration. Patients with Hunner-type IC also exhibited increased expression of p65 and interleukin-1β, suggesting activation of inflammatory response modulation in IC/BPS. These findings suggest that mGluR5 may contribute to pain through immune response modulation in IC/BPS. Targeting mGluR5 could represent a promising therapeutic strategy to alleviate symptoms and improve patient quality of life.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/4025
/ 692/699
/ Adult
/ Aged
/ Biopsy
/ Bladder
/ Cystitis
/ Cystitis, Interstitial - complications
/ Cystitis, Interstitial - genetics
/ Cystitis, Interstitial - metabolism
/ Cystitis, Interstitial - pathology
/ Female
/ Fibrosis
/ Glutamic acid receptors (metabotropic)
/ Humanities and Social Sciences
/ Humans
/ Male
/ Metabotropic glutamate receptor
/ Pain
/ Patients
/ Receptor, Metabotropic Glutamate 5 - genetics
/ Receptor, Metabotropic Glutamate 5 - metabolism
/ Receptors, Metabotropic Glutamate
/ Science
