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Gadolinium based contrast agent induced electrical conductivity heterogeneity analysis in the brain of Alzheimer’s disease
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Gadolinium based contrast agent induced electrical conductivity heterogeneity analysis in the brain of Alzheimer’s disease
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Journal Article
Gadolinium based contrast agent induced electrical conductivity heterogeneity analysis in the brain of Alzheimer’s disease
2025
Overview
Magnetic resonance imaging (MRI) often uses gadolinium-based contrast agents (GBCAs) to improve the characterization of imaging contrast, owing to their strong paramagnetic properties. Magnetic resonance electrical properties tomography (MREPT) visualizes the conductivity distribution of biological tissues at the Larmor frequency using the
field phase signal. In this paper, we investigate the effect of GBCA on brain conductivity. To compare the differences of reconstructed noisy conductivity maps before and after the GBCA injection, we propose a method to remove the background low-frequency noise artifact based on an elliptic partial differential equation. By analyzing the relationship between electrical conductivity and magnetic permeability, the objective of this study is to develop a cost-effective and accessible initial screening imaging tool for diagnosing and monitoring the treatment of Alzheimer’s disease (AD) pathophysiology. To investigate vascular damage in AD, we define a conductivity heterogeneity volume fraction (CHVF) caused by GBCA leakage. Using CHVF, we develop three indices to characterize mild cognitive impairment (MCI) and AD. To verify the proposed method, we studied a total of 42 participants, including 14 individuals diagnosed with AD, 18 participants with MCI, and 10 cognitively normal (CN) participants. Finally, we designed a radar chart informed by the CHVF analysis, to exhibit the pertinent parameters for MCI and AD patients, facilitating the evaluation and ongoing monitoring of each patient’s diagnosis and treatment regimen.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/53
/ Aged
/ Alzheimer Disease - diagnostic imaging
/ Cognitive Dysfunction - diagnostic imaging
/ Conductivity heterogeneity volume fraction
/ Female
/ Gadolinium-based contrast agent
/ Humanities and Social Sciences
/ Humans
/ Magnetic Resonance Imaging - methods
/ Male
/ Partial differential equations
/ Science
