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Evaluation of a novel vaccine candidate derived from newly excysted juveniles of Fasciola hepatica in sheep
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Evaluation of a novel vaccine candidate derived from newly excysted juveniles of Fasciola hepatica in sheep
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Journal Article
Evaluation of a novel vaccine candidate derived from newly excysted juveniles of Fasciola hepatica in sheep
2025
Overview
Vaccine approaches for controlling
Fasciola hepatica
present a promising avenue, particularly considering increasing resistance to anthelmintic treatments and concerns over chemical residues. Targeting vaccine candidates that are expressed and secreted during the early infective stage of
F. hepatica
could offer an effective alternative. This approach aims to inhibit the invasion and migration of juvenile parasites, which have not yet fully developed their immune evasion mechanisms, thereby preventing parasite establishment and development in the host. In this study, we evaluated the host immune response and the protective efficacy of a vaccine cocktail comprising four antigens -KTSPIDP, VGHC1, CRTA, and CAL- in sheep infected with
F. hepatica
. These parasitic antigens were selected based on a proteomic analysis coupled with an “in vitro” interaction model between newly excysted juvenile worms and mouse intestinal epithelial cell cultures. Despite inducing a strong IgG1 response, vaccination did not reduce liver fluke burden nor faecal egg counts. However, it reduced liver pathology caused by the parasite. Our findings highlight the need for further research into early-stage interactions between
F. hepatica
and the host. Understanding these interactions could facilitate the progress of vaccines capable of disrupting parasite development and transmission in livestock, potentially reducing the economic and health impacts associated with fasciolosis.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/699
/ Animals
/ Antibodies, Helminth - immunology
/ Antigens
/ Antigens, Helminth - immunology
/ Fasciola hepatica - immunology
/ Fascioliasis - prevention & control
/ Humanities and Social Sciences
/ Immunoglobulin G - immunology
/ Liver
/ Mice
/ Science
/ Sheep
/ Sheep Diseases - parasitology
/ Sheep Diseases - prevention & control
/ Vaccines
