Journal Article

Skin gluten-related disorders: new and old cutaneous manifestations to be considered

Antiga, Emiliano, Donati, Marta Elettra, Quintarelli, Lavinia, Mariotti, Elena Biancamaria, Corrà, Alberto, Bonciolini, Veronica, Caproni, Marzia, Aimo, Cristina, Verdelli, Alice, Ruffo di Calabria, Valentina

2023

Overview

The term gluten-related disorders (GRD) refer to a spectrum of different clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals, including coeliac disease (CD), wheat allergy and non-celiac gluten sensitivity (NCGS). GRD are characterized by a large variety of clinical presentations with both intestinal and extra-intestinal manifestations. The latter may affect almost every organ of the body, including the skin. Besides the well-known association between CD and dermatitis herpetiformis, considered as the cutaneous specific manifestation of CD, many other muco-cutaneous disorders have been associated to GRD. In this review, we analyzed the main features of dermatological diseases with a proven association with GRD and those that improve after a gluten-free diet, focusing on the newly described cutaneous manifestations associated with NCGS. Our main hypothesis is that a “cutaneous-gluten sensitivity,” as specific cutaneous manifestation of NCGS, may exist and could represent a diagnostic marker of NCGS.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Antibodies / Autoimmune diseases / Biopsy / Celiac disease / coeliac disease / Dermatitis / dermatitis herpetiformis / Erythema / Gluten / gluten-related disorders / Health risk assessment / Immunology / Medicine / Meta-analysis / non-celiac gluten sensitivity / Pediatrics / Permeability / Psoriasis / Psoriatic arthritis / Rosacea / Skin diseases / skin extra-intestinal manifestations / Urticaria / Vitiligo / wheat allergy