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KNN-based frequency-adjustable ferroelectric heterojunction and biomedical applications
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KNN-based frequency-adjustable ferroelectric heterojunction and biomedical applications
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Journal Article
KNN-based frequency-adjustable ferroelectric heterojunction and biomedical applications
2025
Overview
High-performance lead-free K
0.5
Na
0.5
NbO
3
piezoelectric ceramics present a practical alternative to lead-containing counterparts by effectively reducing potential environmental hazards. This advancement is particularly relevant to the development of ferroelectric heterojunction devices for biomedical applications. Here, we design and fabricate a frequency-adjustable ferroelectric heterojunction based on the developed K
0.5
Na
0.5
NbO
3
piezoelectric ceramics with a high piezoelectric coefficient (
d
33
= 680 pC/N). By leveraging flexible encapsulation, the heterojunction achieves miniaturization (
φ
= 13.3 mm,
h
= 2.28 mm) and suitability for implantation. After penetrating the rat skull, the ultrasound generated by the heterojunction at a frequency of 3 MHz reaches a focal depth of about 7.9 mm, a focal width of approximately 480 μm at −6 dB, and millimeter-scale continuous focal tuning (1.5 mm) within a narrow frequency range (2.7–3.3 MHz). Additionally, the implanted heterojunction enables long-term and high-precision transcranial neuromodulation, and consequently yields therapeutic effects in a myocardial infarction animal model. Collectively, this study highlights a viable strategy for developing and applying lead-free ferroelectric heterojunctions, expanding their potential in brain modulation, and providing new insights into clinical treatments of myocardial infarction.
The authors present a frequency-adjustable ferroelectric heterojunction based on K
0.5
Na
0.5
NbO
3
piezoelectric ceramic, which enabling therapeutic effects in a myocardial infarction animal model by long-term and high-precision transcranial neuromodulation.
