Asset Details
Do you wish to reserve the book?
Spatial regulation of chrysosplenetin on amino acid homeostasis linked to artemisinin resistance in Plasmodium berghei K173 based on targeted metabolomics
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Spatial regulation of chrysosplenetin on amino acid homeostasis linked to artemisinin resistance in Plasmodium berghei K173 based on targeted metabolomics
Do you wish to request the book?
Spatial regulation of chrysosplenetin on amino acid homeostasis linked to artemisinin resistance in Plasmodium berghei K173 based on targeted metabolomics
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Spatial regulation of chrysosplenetin on amino acid homeostasis linked to artemisinin resistance in Plasmodium berghei K173 based on targeted metabolomics
2025
Overview
Chrysosplenetin, a polymethoxy flavonol purified in our laboratory from the waste products generated during the industrial extraction of artemisinin, has been previously demonstrated to be a potential inhibitor of artemisinin resistance. Based on NMR-untargeted metabolomics, one of its hypothesized mechanisms of action is associated with the regulation of amino acid metabolism. In this study, we further quantified the key amino acids using LC-MS/MS targeted metabolomics and screened out the perturbed metabolic pathway network, which was characterized by tissue-specific differences. As a result, among the commonly and uniquely altered metabolites, increased levels of phenylalanine, tryptophan, and isoleucine were detected in the serum and various organs of the resistant groups. Interestingly, while the individual use of chrysosplenetin or artemisinin elevated the contents of these amino acids, their combination led to a significant down-regulation of these amino acids in the serum and intestines. Therefore, chrysosplenetin has the potential to act as a restorer of amino acid metabolism homeostasis, which is associated with artemisinin resistance in
Plasmodium berghei
K173.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
