Asset Details
Do you wish to reserve the book?
Multiscale gradients of corticopontine structural connectivity
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Multiscale gradients of corticopontine structural connectivity
Do you wish to request the book?
Multiscale gradients of corticopontine structural connectivity
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Multiscale gradients of corticopontine structural connectivity
2025
Overview
The cerebellum’s involvement in a range of cognitive, emotional, and motor processes has become increasingly evident. Given the uniformity of the cerebellar cortex’s cellular architecture its contributions to varied processes are thought be partially mediated by its patterns of reciprocal connectivity with the rest of the brain. A better understanding of these connections is therefore fundamental to disentangling the cerebellum’s contribution to cognition and behavior. While these connections have been studied extensively in non-human animals using invasive methods, we have limited knowledge of these connections in humans. The current work reconstructed the corticopontine projection, the first segment of downstream connections between the cerebral and cerebellar cortices, with diffusion MRI tractography in human in-vivo whole brain data and an independent higher resolution postmortem brainstem dataset. Dimensionality reduction was used to characterize the pattern of connectivity of cerebral cortical projections to the pons as two overlapping gradients that were consistent across participants and datasets: medial to lateral and core to belt. Our findings align with invasive work done in animals and advance our understanding of this connection in humans – providing valuable context to a growing body of cerebellar research, offering insights into impacts of damage along the pathway, and informing clinical interventions.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Adult
/ Animals
/ Cerebellar Cortex - anatomy & histology
/ Cerebellar Cortex - diagnostic imaging
/ Cerebellar Cortex - physiology
/ Cerebral Cortex - anatomy & histology
/ Cerebral Cortex - diagnostic imaging
/ Cerebral Cortex - physiology
/ Datasets
/ Female
/ Humanities and Social Sciences
/ Humans
/ Male
/ Neural Pathways - anatomy & histology
/ Neural Pathways - physiology
/ Pons
/ Science
