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Implications of Tuberculosis Reactivation after Immune Checkpoint Inhibition
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Journal Article
Implications of Tuberculosis Reactivation after Immune Checkpoint Inhibition
2018
Overview
Antituberculosis treatment was initiated, which led to clinical improvement, normalization of liver function tests, and regression of the lung lesion. [...]the unifying diagnosis was disseminated TB associated with immune checkpoint inhibition. [...]this clinical occurrence runs counter to the current disease paradigm, which proposes that active TB results from a deficient host immune response (1). [...]we performed immunohistochemical analysis of TB lung lesions in the context of a normal immune response (six cases) and the lung biopsy of this case. [...]it seems highly counterintuitive that PD-1 blockade should also cause activation of TB, as by this paradigm anti-PD-1 therapy should improve host control of TB.
Publisher
American Thoracic Society
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