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Plasma concentrations of IL-6, MIP-1β, IP-10, and PTX-3 as predictors of the immunological response to antiretroviral treatment in people with HIV
by
Sotomayor, Cesar
, Herrero, Marta
, Mejías-Trueba, Marta
, Serna-Gallego, Ana
, López-Cortes, Luis F.
, Espinosa, Nuria
, Muñoz-Muela, Esperanza
, Saborido-Alconchel, Abraham
, Trujillo-Rodríguez, María
, Llaves-Flores, Silvia
, Roca-Oporto, Cristina
in
Adult
/ Anti-HIV Agents - therapeutic use
/ Anti-Retroviral Agents - therapeutic use
/ Antiretroviral therapy
/ Antiretroviral Therapy, Highly Active
/ Biomarkers - blood
/ Body mass index
/ C-Reactive Protein - analysis
/ C-Reactive Protein - metabolism
/ CD4 antigen
/ CD4-CD8 Ratio
/ CD8 antigen
/ Chemokine CCL4 - blood
/ Chemokine CXCL10 - blood
/ Chemokines
/ Female
/ Hepatitis
/ HIV
/ HIV infection
/ HIV Infections - blood
/ HIV Infections - drug therapy
/ HIV Infections - immunology
/ Human immunodeficiency virus
/ Humans
/ IL-6
/ Immune response
/ immunologic response
/ Immunology
/ Infections
/ Interleukin 6
/ Interleukin-6 - blood
/ IP-10
/ IP-10 protein
/ Lymphocytes
/ Lymphocytes T
/ Macrophage inflammatory protein
/ Macrophage inflammatory protein 1
/ Male
/ Middle Aged
/ MIP-1β
/ Pentraxins
/ Plasma
/ Plasma levels
/ PTX-3
/ Serum Amyloid P-Component - metabolism
/ Software
/ Treatment Outcome
/ Variables
2024
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Plasma concentrations of IL-6, MIP-1β, IP-10, and PTX-3 as predictors of the immunological response to antiretroviral treatment in people with HIV
by
Sotomayor, Cesar
, Herrero, Marta
, Mejías-Trueba, Marta
, Serna-Gallego, Ana
, López-Cortes, Luis F.
, Espinosa, Nuria
, Muñoz-Muela, Esperanza
, Saborido-Alconchel, Abraham
, Trujillo-Rodríguez, María
, Llaves-Flores, Silvia
, Roca-Oporto, Cristina
in
Adult
/ Anti-HIV Agents - therapeutic use
/ Anti-Retroviral Agents - therapeutic use
/ Antiretroviral therapy
/ Antiretroviral Therapy, Highly Active
/ Biomarkers - blood
/ Body mass index
/ C-Reactive Protein - analysis
/ C-Reactive Protein - metabolism
/ CD4 antigen
/ CD4-CD8 Ratio
/ CD8 antigen
/ Chemokine CCL4 - blood
/ Chemokine CXCL10 - blood
/ Chemokines
/ Female
/ Hepatitis
/ HIV
/ HIV infection
/ HIV Infections - blood
/ HIV Infections - drug therapy
/ HIV Infections - immunology
/ Human immunodeficiency virus
/ Humans
/ IL-6
/ Immune response
/ immunologic response
/ Immunology
/ Infections
/ Interleukin 6
/ Interleukin-6 - blood
/ IP-10
/ IP-10 protein
/ Lymphocytes
/ Lymphocytes T
/ Macrophage inflammatory protein
/ Macrophage inflammatory protein 1
/ Male
/ Middle Aged
/ MIP-1β
/ Pentraxins
/ Plasma
/ Plasma levels
/ PTX-3
/ Serum Amyloid P-Component - metabolism
/ Software
/ Treatment Outcome
/ Variables
2024
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Plasma concentrations of IL-6, MIP-1β, IP-10, and PTX-3 as predictors of the immunological response to antiretroviral treatment in people with HIV
by
Sotomayor, Cesar
, Herrero, Marta
, Mejías-Trueba, Marta
, Serna-Gallego, Ana
, López-Cortes, Luis F.
, Espinosa, Nuria
, Muñoz-Muela, Esperanza
, Saborido-Alconchel, Abraham
, Trujillo-Rodríguez, María
, Llaves-Flores, Silvia
, Roca-Oporto, Cristina
in
Adult
/ Anti-HIV Agents - therapeutic use
/ Anti-Retroviral Agents - therapeutic use
/ Antiretroviral therapy
/ Antiretroviral Therapy, Highly Active
/ Biomarkers - blood
/ Body mass index
/ C-Reactive Protein - analysis
/ C-Reactive Protein - metabolism
/ CD4 antigen
/ CD4-CD8 Ratio
/ CD8 antigen
/ Chemokine CCL4 - blood
/ Chemokine CXCL10 - blood
/ Chemokines
/ Female
/ Hepatitis
/ HIV
/ HIV infection
/ HIV Infections - blood
/ HIV Infections - drug therapy
/ HIV Infections - immunology
/ Human immunodeficiency virus
/ Humans
/ IL-6
/ Immune response
/ immunologic response
/ Immunology
/ Infections
/ Interleukin 6
/ Interleukin-6 - blood
/ IP-10
/ IP-10 protein
/ Lymphocytes
/ Lymphocytes T
/ Macrophage inflammatory protein
/ Macrophage inflammatory protein 1
/ Male
/ Middle Aged
/ MIP-1β
/ Pentraxins
/ Plasma
/ Plasma levels
/ PTX-3
/ Serum Amyloid P-Component - metabolism
/ Software
/ Treatment Outcome
/ Variables
2024
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Plasma concentrations of IL-6, MIP-1β, IP-10, and PTX-3 as predictors of the immunological response to antiretroviral treatment in people with HIV
Journal Article
Plasma concentrations of IL-6, MIP-1β, IP-10, and PTX-3 as predictors of the immunological response to antiretroviral treatment in people with HIV
2024
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Overview
Despite effective antiretroviral therapy (ART), 15-30% of people with HIV experience poor CD4 + T-cell recovery, termed immunologic non-responders (INR). This study aims to evaluate whether pre-ART plasma levels of interleukin-6 (IL-6), interferon gamma-induced protein-10 (IP-10), macrophage inflammatory protein-1-β (MIP-1β), and/or pentraxin-3 (PTX-3) could predict subsequent immunologic recovery. Seventy-four participants were enrolled and classified as INR and immunologic responders (IR) based on CD4 + /CD8 + ratio increase over 24 months after starting ART. The results showed no significant differences in cytokine levels between INR and IR. Therefore, IL-6, IP-10, MIP-1β, and PTX-3 were unsuitable as predictive markers of poor immune recovery.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Anti-HIV Agents - therapeutic use
/ Anti-Retroviral Agents - therapeutic use
/ Antiretroviral Therapy, Highly Active
/ C-Reactive Protein - analysis
/ C-Reactive Protein - metabolism
/ Female
/ HIV
/ HIV Infections - drug therapy
/ Human immunodeficiency virus
/ Humans
/ IL-6
/ IP-10
/ Macrophage inflammatory protein
/ Macrophage inflammatory protein 1
/ Male
/ MIP-1β
/ Plasma
/ PTX-3
/ Serum Amyloid P-Component - metabolism
/ Software
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