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Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation
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Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation
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Journal Article
Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation
2001
Overview
Astrocytes respond to chemical, electrical and mechanical stimuli with transient increases in intracellular calcium concentration ([Ca
2+
]
i
). We now show that astrocytes
in situ
display intrinsic [Ca
2+
]
i
oscillations that are not driven by neuronal activity. These spontaneous astrocytic oscillations can propagate as waves to neighboring astrocytes and trigger slowly decaying NMDA receptor-mediated inward currents in neurons located along the wave path. These findings show that astrocytes
in situ
can act as a primary source for generating neuronal activity in the mammalian central nervous system.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Biological Clocks - drug effects
/ Biological Clocks - physiology
/ Biomedical and Life Sciences
/ Calcium Channel Blockers - pharmacology
/ Calcium Signaling - drug effects
/ Calcium Signaling - physiology
/ Central Nervous System - cytology
/ Central Nervous System - drug effects
/ Central Nervous System - metabolism
/ Enzyme Inhibitors - pharmacology
/ Excitatory Amino Acid Antagonists - pharmacology
/ GABA Antagonists - pharmacology
/ Isoquinolines - pharmacokinetics
/ Lysine - analogs & derivatives
/ Membrane Potentials - drug effects
/ Membrane Potentials - physiology
/ Neurons
/ Rats
/ Receptors, N-Methyl-D-Aspartate - drug effects
/ Receptors, N-Methyl-D-Aspartate - metabolism
/ Synaptic Transmission - drug effects
