Journal Article

Threading the Pieces Together: Integrative Perspective on SARS-CoV-2

Mishra, Neha, Khan, Azka, Sharma, Sachin, Srinivasa Vasudevan, Janani, Kanakan, Akshay, Sahni, Shweta, Pandey, Rajesh

2020

Overview

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has challenged the research community globally to innovate, interact, and integrate findings across hierarchies. Research on SARS-CoV-2 has produced an abundance of data spanning multiple parallels, including clinical data, SARS-CoV-2 genome architecture, host response captured through transcriptome and genetic variants, microbial co-infections (metagenome), and comorbidities. Disease phenotypes in the case of COVID-19 present an intriguing complexity that includes a broad range of symptomatic to asymptomatic individuals, further compounded by a vast heterogeneity within the spectrum of clinical symptoms displayed by the symptomatic individuals. The clinical outcome is further modulated by the presence of comorbid conditions at the point of infection. The COVID-19 pandemic has produced an expansive wealth of literature touching many aspects of SARS-CoV-2 ranging from causal to outcome, predisposition to protective (possible), co-infection to comorbidity, and differential mortality globally. As challenges provide opportunities, the current pandemic’s challenge has underscored the need and opportunity to work for an integrative approach that may be able to thread together the multiple variables. Through this review, we have made an effort towards bringing together information spanning across different domains to facilitate researchers globally in pursuit of their response to SARS-CoV-2.

• Publisher: MDPI AG,MDPI
• Subject: Aerosols / architecture / co-infection / comorbidity / Concurrent infection / Coronavirus infections / Coronaviruses / COVID-19 / Disease transmission / drugs / Epidemics / Epidemiology / Gene expression / Genes / Genetic diversity / Genetic variance / genetic variation / genome / Genomes / Heterogeneity / Hierarchies / host response / Infections / information / integrative genomics / literature / metagenomics / Microorganisms / Middle East respiratory syndrome / mixed infection / mortality / Mutation / pandemic / Pandemics / Pathogens / phenotype / Phenotypes / Pneumonia / Proteins / researchers / Respiratory diseases / Review / RNA polymerase / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus / Severe acute respiratory syndrome coronavirus 2 / Signs and symptoms / signs and symptoms (animals and humans) / transcriptome / Transcriptomes / Viral diseases / Viruses