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Arthropod Ectoparasites Have Potential to Bind SARS-CoV-2 via ACE
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Journal Article
Arthropod Ectoparasites Have Potential to Bind SARS-CoV-2 via ACE
2021
Overview
Coronavirus-like organisms have been previously identified in Arthropod ectoparasites (such as ticks and unfed cat flea). Yet, the question regarding the possible role of these arthropods as SARS-CoV-2 passive/biological transmission vectors is still poorly explored. In this study, we performed in silico structural and binding energy calculations to assess the risks associated with possible ectoparasite transmission. We found sufficient similarity between ectoparasite ACE and human ACE2 protein sequences to build good quality 3D-models of the SARS-CoV-2 Spike:ACE complex to assess the impacts of ectoparasite mutations on complex stability. For several species (e.g., water flea, deer tick, body louse), our analyses showed no significant destabilisation of the SARS-CoV-2 Spike:ACE complex, suggesting these species would bind the viral Spike protein. Our structural analyses also provide structural rationale for interactions between the viral Spike and the ectoparasite ACE proteins. Although we do not have experimental evidence of infection in these ectoparasites, the predicted stability of the complex suggests this is possible, raising concerns of a possible role in passive transmission of the virus to their human hosts.
Publisher
MDPI AG,MDPI
Subject
/ Angiotensin-converting enzyme 2
/ Angiotensin-Converting Enzyme 2 - chemistry
/ Angiotensin-Converting Enzyme 2 - genetics
/ Angiotensin-Converting Enzyme 2 - metabolism
/ Animals
/ Arthropod Proteins - chemistry
/ Arthropod Proteins - genetics
/ Arthropod Proteins - metabolism
/ Cats
/ COVID-19
/ Ectoparasitic Infestations - parasitology
/ energy
/ Humans
/ Mutation
/ parasite
/ Peptidyl-Dipeptidase A - chemistry
/ Peptidyl-Dipeptidase A - genetics
/ Peptidyl-Dipeptidase A - metabolism
/ Proteins
/ Severe acute respiratory syndrome coronavirus 2
/ Spike Glycoprotein, Coronavirus - chemistry
/ Spike Glycoprotein, Coronavirus - genetics
/ Spike Glycoprotein, Coronavirus - metabolism
/ Vectors
/ Viruses
/ Zoonoses
