Asset Details
Do you wish to reserve the book?
Epistatic Interaction of ERAP1 and HLA-B51 in Iranian Patients with Behçet’s Disease
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Epistatic Interaction of ERAP1 and HLA-B51 in Iranian Patients with Behçet’s Disease
Do you wish to request the book?
Epistatic Interaction of ERAP1 and HLA-B51 in Iranian Patients with Behçet’s Disease
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Epistatic Interaction of ERAP1 and HLA-B51 in Iranian Patients with Behçet’s Disease
2018
Overview
Behçet’s Disease (BD) pathogenesis remains unclear, but some genetic loci and environmental factors are proposed to play a role. Here, we investigate the association of the endoplasmic reticulum aminopeptidase-1 (
ERAP1
) gene variants and
HLA-B*51
with BD susceptibility and clinical manifestations in Iranian patients. In the study, 748 BD patients and 776 healthy individuals were included. The MGB-TaqMan Allelic Discrimination method was used to genotype 10 common missense single nucleotide polymorphisms (SNPs) and one intronic SNP in the
ERAP1
gene region. We found no significant association between the 11 SNPs and BD in allelic and genotypic association tests. However, rs30187 showed the strongest association with BD in the recessive genotype model of the risk T allele in
HLA-B*51
carriers. Although this became insignificant after correcting for multiple comparisons, the homozygous rs30187 risk allele genotype (TT) increased disease susceptibility in
HLA-B*51
carriers in epistasis analysis, and the rs30187 TT recessive genotype showed a significant association with risk of cardiac involvement in the all patients and articular involvements in
HLA-B*51
positive patients. Our findings suggest that gene-gene interactions between
HLA-B*51
and
ERAP1
variants is important for BD development, however,
ERAP1
variants which interact with
HLA-B*51
may differ among disease phenotypes or populations.
Publisher
Springer Science and Business Media LLC,Nature Publishing Group UK,Nature Publishing Group
Subject
/ 45/77
/ 631/208
/ 631/250
/ Adult
/ Aged
/ Alleles
/ Child
/ Female
/ Genetic Predisposition to Disease
/ Histocompatibility antigen HLA
/ Humanities and Social Sciences
/ Humans
/ Infant
/ Iran
/ Male
/ Minor Histocompatibility Antigens
/ Polymorphism, Single Nucleotide
/ Science
