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Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists

by Nakamura, M. , Kobayashi, T. , Shibata, Y. , Nakamoto, M. , Bhandari, R. K. , Nagahama, Y. , Kobayashi, Y. , Paul-Prasanth, B. , Horiguchi, R. , Sakai, F.

in 17β-Estradiol / 631/136/142 / 631/136/1660/1986 / 631/136/2434/1706 / 631/443/163/812 / Animals / Aromatase / Behavior, Animal / Biomarkers / Cell Differentiation / Cysts / Estradiol - metabolism / Estradiol - pharmacology / Estrogens / Estrogens - metabolism / Estrogens - pharmacology / Female / Fish / Fishes - genetics / Fishes - metabolism / Germ cells / Germ Cells - cytology / Germ Cells - metabolism / Gonadal Steroid Hormones - biosynthesis / Gonads / Gonads - cytology / Gonads - drug effects / Gonads - metabolism / Humanities and Social Sciences / Leydig Cells - cytology / Leydig Cells - metabolism / Male / multidisciplinary / Ovaries / Phenotype / Plasticity / Reproduction / Science / Secondary sexual characters / Sertoli cells / Sex Characteristics / Sex differentiation / Sex Differentiation - drug effects / Sex Differentiation - physiology / Sex reversal / Sexual behavior / Testis - physiology

2013

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Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists

by Nakamura, M. , Kobayashi, T. , Shibata, Y. , Nakamoto, M. , Bhandari, R. K. , Nagahama, Y. , Kobayashi, Y. , Paul-Prasanth, B. , Horiguchi, R. , Sakai, F.

2013

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Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists

by Nakamura, M. , Kobayashi, T. , Shibata, Y. , Nakamoto, M. , Bhandari, R. K. , Nagahama, Y. , Kobayashi, Y. , Paul-Prasanth, B. , Horiguchi, R. , Sakai, F.

2013

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Journal Article

Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists

Nakamura, M.,

Kobayashi, T.,

Shibata, Y.,

Nakamoto, M.,

Bhandari, R. K.,

Nagahama, Y.,

Kobayashi, Y.,

Paul-Prasanth, B.,

Horiguchi, R.,

Sakai, F.

2013

Overview

The sexual plasticity of the gonads is not retained after the completion of sex differentiation in vertebrates, except in some hermaphroditic species. Here, we report that the depletion of estradiol-17β (E 2 ) by aromatase inhibitors (AI) for up to six months resulted in a functional female-to-male sex reversal in sexually-mature adults of two gonochoristic fish species, Nile tilapia and medaka. The sex-reversed fish showed a typical male pattern of E 2 and androgen levels, secondary sexual characteristics and male-like sex behavior, producing fertile sperm. Conversely, co-treatment of E 2 inhibited AI-induced sex reversal. In situ hybridization of medaka gonads during AI-induced sex reversal indicated that cysts on the dorsal side of the adult ovaries are the origin of germ cells and Sertoli cells in the newly formed testicular tissue. Gonochoristic fish maintain their sexual plasticity until adulthood and E 2 plays a critical role in maintaining the female phenotype.

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

/ Animals